军事医学Issue(11)：881-883,3.DOI:10.7644/j.issn.1674-9960.2015.11.017
富马酸二甲酯在多发性硬化中的应用及其机制研究进展
Application and mechanism of dimethylfumarate in MS:research progress
摘要
Abstract
Multiple sclerosis(MS)is a demyelinating disease of the central nervous system and one of the most common autoimmune diseases,characterized by wide-spread lesions and relapsing-remitting encephalomyelitis,accompanied by optic nerve damage.Patients worldwide total about 2.5 million,mostly young adults and women.This disease remains incurable. Dimethylfumarate (DMF)is a new oral drug for MS,which was approved by the FDA in 2013 for clinical treatment of re-lapsing-remitting MS.It can reduce the activity of disease,and the relapsing-remitting MS relapse.This paper outlines the application of DMF to the treatment of MS and its mechanism of action.关键词
富马酸二甲酯/多发性硬化/NF-E2 相关因子 2/T 淋巴细胞Key words
dimethylfumarate/multiple sclerosis/NF-E2 related factor 2/T-lymphocytes分类
医药卫生引用本文复制引用
李娜,李金亮,王仁喜,肖鹤..富马酸二甲酯在多发性硬化中的应用及其机制研究进展[J].军事医学,2015,(11):881-883,3.基金项目
国家自然科学基金资助项目 （）
