临床神经外科杂志Issue(6)：435-437,441,4.DOI:10.3969/j.issn.1672-7770.2015.06.009
异甘草酸镁对创伤性脑损伤后肝损害保护机制的研究
Mechanism of magnesium isoglycyrrhizinate on the protection of liver damage after traumatic brain injury
李健 1陆海 1郑晶1
作者信息
- 1. 223800 南京鼓楼医院集团宿迁市人民医院神经外科
- 折叠
摘要
Abstract
Objective To investigate the mechanism of magnesium isoglycyrrhizinate on the protection of liver damage after traumatic brain injury( TBI) .Methods The rats with liver damage after TBI were injected magnesium isoglycyrrhizinate intraperitoneally one day after, 30 mg /kg, one time every day for 5 days.And the serum level of ALT and AST were determined, the level of serum tumor necrosis factor-α( TNF-α) was determined by ELISA, the level of TNF-αmRNA in liver was determined by real-time PCR and the expression of nuclear transcription factors-kappa B ( NF-κB) in liver was determined by Western-Blot.Results The level of serum ALT/AST in the rats which were injected magnesium isoglycyrrhizinatewere higher than the normal rats, the level of TNF-αin blood and liver and the expression of NF-κB in liver of the rats with magnesium isoglycyrrhizinate were more reduced significantly than those without magnesium isoglycyrrhizinate injection.Conclusion Magnesium isoglycyrrhizinate can reduce the level of TNF-αby NF-κB pathway in order to protect the liver function.关键词
异甘草酸镁/颅脑损伤/肝损伤/肿瘤坏死因子α/核转录因子kappa BKey words
magnesium isoglycyrrhizinate/traumatic brain injury/liver damage/tumor necrosis factor-α/Nuclear transcription factors-kappa B分类
医药卫生引用本文复制引用
李健,陆海,郑晶..异甘草酸镁对创伤性脑损伤后肝损害保护机制的研究[J].临床神经外科杂志,2015,(6):435-437,441,4.
