实用医学杂志2015，Vol.31Issue(22)：3684-3687,4.DOI:10.3969/j.issn.1006-5725.2015.22.017
溃疡性结肠炎患者DR4和DR5基因单核苷酸多态性分析
Association of single nucleotide polymorphisms of DR4 and DR5 gene with ulcerative colitis
摘要
Abstract
Objective To investigate the association of death receptor (DR)4 and DR5 gene polymorphisms with ulcerative colitis (UC). Methods The genotypes of DR4 (rs20575) and DR5 (rs1047266) genes were detected by using DNA sequencing in 163 UC patients and 252 healthy controls. Results Compared to the healthy controls, the frequencies of variant allele G and genotype CG+GG of DR4 (rs20575) were significantly increased in the UC patients (6.75% vs 1.39%, P < 0.001, OR = 5.138; 8.59% vs 2.78%, P =0.008,OR = 3.289). The further stratified analysis showed that the variant genotype CG+GG of DR4 (rs20575) was significantly higher in patients with severe UC than those with mild and moderated UC(20.83% vs 6.47%, P = 0.020, OR = 3.801). Moreover, variant allele G of DR4 (rs20575) was significantly lower in patients with extensive UC than those with distal UC (2.34% vs 9.60%, P = 0.011, OR = 0.226). In addition, no significant relationship was found between DR5 (rs1047266) gene polymorphism and UC. Conclusions The DR4 (rs20575) gene polymorphism was associated with the susceptibility, as well as the severity and location, of UC in Chinese patients. However, DR5 (rs1047266) polymorphism was not associated with UC.关键词
溃疡性结肠炎/TRAIL/死亡受体/基因多态性Key words
Ulcerative colitis/TRAIL/Death receptor/Genetic polymorphism引用本文复制引用
姜利佳,朱丽明,胡向跃,李成安,金捷,杜君彦,黄志养,黄春伟,蔡静..溃疡性结肠炎患者DR4和DR5基因单核苷酸多态性分析[J].实用医学杂志,2015,31(22):3684-3687,4.基金项目
2013年省卫生厅一般项目(编号:2013KYB251) （编号:2013KYB251）
