医药导报2015，Vol.34Issue(12)：1627-1632,6.DOI:10.3870/j.issn.1004-0781.2015.12.020
曲克芦丁微乳的处方筛选及含量测定
Formulation Screening and Determination of Troxerutin Microemulsion
摘要
Abstract
Objective To optimize a W/O microemulsion formulation of troxerutin and evaluate its physical properties such as morphology, droplet size, stability and content of troxerutin. Methods The W/O microemulsion was optimized using a pseudoternary phase diagram and the area of the microemulsion region was used to screen and determine microemulsion components.HPLC assay was used for determination of the loading content. Results The optimal formulation contained lecithin, ethanol, isopropyl myristate and water (23.30:11.67:52.45:12.59).The microemulsion was physicochemically stable with round shape and uniform size, and the mean droplet size was about 50. 20 nm. Conclusion Microemulsion was developed successfully.It will expect to be the new preparation for troxerutin.关键词
曲克芦丁/伪三元相图/微乳/质量评价Key words
Troxerutin/Pseudoternary phase diagram/Microemulsion/Quality evaluation分类
医药卫生引用本文复制引用
许曼,余庆,赵倩茹,陈伟,林元节,金涌..曲克芦丁微乳的处方筛选及含量测定[J].医药导报,2015,34(12):1627-1632,6.基金项目
安徽省高校自然科学基金重点项目(KJ2013A153) （KJ2013A153）
