中国医学前沿杂志（电子版）Issue(10)：41-44,4.
联合检测HE4、CA125、CA19-9和CEA在卵巢癌诊断中的应用
Application of combined detection of HE4, CA19-9, CA125 and CEA in the diagnosis of ovarian cancer
摘要
Abstract
ObjectiveTo discuss the application value of HE4, CA125, CA19-9 and CEA in the diagnosis of ovarian cancer.Method75 patients who were diagnosed as ovarian cancer and didn't accept surgery were selected and assigned into cancer group, 75 patients with benign gynecologic disease were selected and assigned into benign disease group, 75 healthy women were selected into control group. Tested the levels of HE4, CA125, CA19-9 and CEA in the three groups, and compared the diagnosibility of ovarian cancer among the single detection and combined detection.ResultThe levels of HE4, CA125, CA19-9 and CEA in cancer group were all obviously higher than benign disease group and control group (P<0.01), and the levels of HE4, CA125, CA19-9 and CEA in benign disease group were higher than control group (P<0.05); in single detection, the sensitivity of HE4 and CA125 were both higher than sensitivity of CA19-9 and CEA (P<0.05); the diagnose accordance rate of HEA and CA125 were both higher than sensitivity of CA19-9 and CEA (P<0.01); the sensitivity of combined detection was higher than single detection (P<0.01); the diagnose accordance rate of combined detection was not different from HE4 and CA125 (P>0.05); single detection of four kinds of tumor marker had low diagnosibility forⅠandⅡstage of ovarian cancer; the sensitivity of combined detection forⅠ,Ⅱ andⅢstage of ovarian cance were higher than single detection (P<0.01). ConclusionThe sensitivity of combined detection of HE4, CA19-9, CA125 and CEA in the diagnosis of ovarian cancer is signiifcantly higher than single detection, combined diagnosis has the advantage of early diagnosis of ovarian cancer.关键词
人附睾分泌蛋白4/糖类抗原125/糖类抗原19-9/癌胚抗原/卵巢癌Key words
HE4/CA125/CA19-9/CEA/Ovarian cancer引用本文复制引用
龚红霞,徐明娟..联合检测HE4、CA125、CA19-9和CEA在卵巢癌诊断中的应用[J].中国医学前沿杂志（电子版）,2015,(10):41-44,4.基金项目
上海长海医院“1255”学科建设计划资助项目 （）
