中国医学前沿杂志（电子版）Issue(10)：133-136,4.
MHV-3诱导小鼠暴发性肝衰竭的机制研究及夏枯草总三萜的改善作用
Research of the mechanism of MHV-3 induced fulminant hepatic failure in mice and the improvement of total triterpenoid of prunella vulgaris L
崔宝林 1任晓菊1
作者信息
- 1. 宝鸡市妇幼保健院 普外科，陕西 宝鸡721000
- 折叠
摘要
Abstract
ObjectiveTo study the mechanism of MHV-3 induced fulminant hepatic failure in mice and the improvement of total triterpenoid of prunella vulgaris L, to provide a reference for the clinical treatment of liver failure and new drug research and development.MethodMale Kunming mice were randomly divided into control group, model group, total triterpenoid of prunella vulgaris L group and PD98059 group. The fulminant hepatic failure mice were duplicated by injection of MHV-3. The other groups mice were received responding drug administration. Analysed of serum levels of inlfammatory factors and MEK/ERK pathway related protein expression in liver tissue of mice after injection of MHV-3.ResultModel group serum levels of interleukin (IL)-2, IL-6 and IL-10 levels were signiifcantly higher (P<0.05), and ERK signaling pathway protein Ras, Raf, MEK, ERK1/2 expression were signiifcantly increased (P<0.05), compared with control group differences were statistically signiifcant (P<0.05). The abnormal expression of inlfammatory cytokines and ERK pathway of mice in PD98059 and total triterpenoid of prunella vulgaris L group were signiifcantly restored (P<0.05).ConclusionTotal triterpenoid of prunella vulgaris L can inhibit excessive activation of MEK/ERK signaling pathway and inlfammatory reaction to improve mice fulminant hepatic failure.关键词
暴发性肝衰竭/炎性因子/ERK信号通路Key words
Fulminant hepatic failure/Inlfammatory factor/ERK signaling pathway引用本文复制引用
崔宝林,任晓菊..MHV-3诱导小鼠暴发性肝衰竭的机制研究及夏枯草总三萜的改善作用[J].中国医学前沿杂志（电子版）,2015,(10):133-136,4.
