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野木瓜注射液HPLC指纹图谱研究

杨毅生 钟瑞建 洪挺 王栋

中国医药科学Issue(19):58-60,78,4.
中国医药科学Issue(19):58-60,78,4.

野木瓜注射液HPLC指纹图谱研究

Study on HPLC fingerprint of Yemugua injection

杨毅生 1钟瑞建 1洪挺 1王栋2

作者信息

  • 1. 江西省药品检验检测研究院 江西省药品与医疗器械质量工程技术研究中心,江西南昌330029
  • 2. 江西省食品检验检测研究院,江西南昌 330046
  • 折叠

摘要

Abstract

Objective To establish the HPLC fingerprint analysis for the quality of Yemugua injection.Methods RP-HPLC method was conducted on a Zorbax SB-C18 column(4.6mm×250mm,5μm)with the gradient elution solvent system composed of acetontrile(A) and 0.5% acetic acid (B)(0~40min,95%→70% B;40~60min, 70%→50% B). The flow rate was 1.0mL/min,the detection wavelength was set at 326nm and the column temperature was maintained at 25℃. ResultsUsing special software,we got the HPLC fingerprint similarity of 35 injection and found the similarity>0.90.Conclusion The method is simple and reliable,and it is capable of effectively controlling the quality of Yemugua injection.

关键词

野木瓜注射液/反相高效液相色谱法/指纹图谱

Key words

Yemugua injection/RP-HPLC/Fingerprint

分类

医药卫生

引用本文复制引用

杨毅生,钟瑞建,洪挺,王栋..野木瓜注射液HPLC指纹图谱研究[J].中国医药科学,2015,(19):58-60,78,4.

基金项目

江西省自然科学基金(20142BAB205086)。 ()

中国医药科学

2095-0616

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