摘要
Abstract
ObjectiveTo explore Effects of dexmedetomidine on hemodynamics during general anaesthetic induction of elderly patients with hypertension.Methods 200 elderly patients with hypertension who were admitted to our hospital and received general anesthesia in operations from January 2010 to December 2014 were randomly allocated to the observation group and the control group, with 100 in each. 100 patients in the observation group were given routine drugs while 100 patients in the control group were given dexmedetomidine at the basis of routine drugs. Systolic blood pressure, diastolic blood pressure, heart rate and rate pressure product (RPP) before anesthesia (T0), after infusion of dexmedetomidine (T1), after general anaesthetic induction (T2), 1min(T3)、3min(T4)、5min(T5) after tracheal intubation of patients were observed. In addition, using times of vasoactive drugs of patients in two groups were observed and analyzed statistically.Results Heart rate of the observation group was decreased at T1. Differences between heart rate at T2, T3, T4 and T5 and heart rates at T1 had statistical significance (P<0.05). In addition, Differences between heart rate at T1, T2, T3, T4 and T5 of the observation group and of the control group had statistical significance (P<0.05). HR of the control group was decreased at T2 and difference had statistical significance compared with HR at T0 (P<0.05). Systolic blood pressure of two groups at T3, T4 and T5 had no obvious changes. But systolic blood pressure of two groups at T2 was decreased compared with that at T1. Difference had statistical significance (P<0.05). But decreasing degree of the observation group was smaller than that of the control group and the difference had statistical significance (P<0.05). Diastolic blood pressure of two groups were both decreased at T2 and T5 compared with that at T0 (P<0.05). But decreasing degree of the observation group was smaller than that of the control group and the difference had statistical significance (P<0.05). RPP at T1, T2, T3, T4 and T5 of the observation group were all decreased compared with that at T0 (P<0.05). RPP at T1, T3, T4 and T5 of the observation group were all decreased compared with that at T1, T3, T4 and T5 of the control group (P<0.05). RPP of the control group were decreased at T2 and T5 and difference had statistical significance compared with RPP at T0 (P<0.05). In the observation group, there were 4 cases of atropine, 4 cases of ephedrine and 2 cases of nitroglycerin. The total using rate was 10.0%. The difference between the two groups was not statistically significant (P>0.05). Conclusion Application of dexmedetomidine in anaesthetic induction of elderly patients with hypertension can maintain hemodynamic stability during induction and inhibit cardiovascular response to tracheal intubation effectively.关键词
右美托咪啶/高血压/全麻诱导/血流动力学Key words
Dexmedetomidine/Hypertension/General anaesthetic induction/Hemodynamics分类
医药卫生
