山东医药2015，Vol.55Issue(45)：8-10,3.DOI:10.3969/j.issn.1002-266X.2015.45.003
肝癌组织中 NF-κBp65 的表达变化及意义
Expression changes of NF-κBp65 in hepatocellular carcinoma tissues and its clinical significance
摘要
Abstract
Objective To detect the expression changes of nuclear transcription factor ( NF)-κBp65 in the hepatocel-lular carcinoma ( HCC) tissues and to explore its clinical significance .Methods The expression of NF-κBp65 protein was detected by immunohistochemistry in the resected HCC tissues , adjacent tissues and normal liver tissues through sur-gery.Results The positive expression rates of NF-κBp65 protein in the HCC tissues, adjacent tissues and normal tissues were 60.67%, 22.67%and 12.00%, respectively.There were significant differences between each two groups (all P<0.05).The positive rates of NF-κBp65 in HCC tissues with positive or negative HBsAg were 64.44%and 26.67%, and the difference was statistically significant (P<0.05).The positive expression of NF-κBp65 protein was related with patho-logical grade and lymph node metastasis (all P<0.05).The survival time distribution of NF-κBp65 negative group was better than that of the NF-κBp65 positive group, but the difference was not significant (P>0.05).Conclusions The ex-pression of NF-κBp65 was increased significantly in the carcinoma tissues of HCC patients , and the positive expression rate is high in HBV positive cancer tissues .NF-κBp65 may be involved in the occurrence and development of liver cancer .关键词
肝肿瘤/肝癌/核转录因子/核转录因子-κBp65Key words
liver neoplasms/liver carcinoma/nuclear transcription factor-κBp65分类
医药卫生引用本文复制引用
陈增银,赵业民,商和振,史光军..肝癌组织中 NF-κBp65 的表达变化及意义[J].山东医药,2015,55(45):8-10,3.基金项目
青岛市卫生局课题(2007Y004). （2007Y004）
