北京大学学报（医学版）2015，Vol.47Issue(6)：905-909,5.DOI:10.3969/j.issn.1671-167X.2015.06.003
CMTM5基因rs723840单核苷酸多态性与阿司匹林治疗下血小板高反应性的相关性研究
Association between CMTM5 gene rs723840 single nucleotide polymorphism and high on asprin platelet reactivity
摘要
Abstract
Objective: To elucidate the correlation between the single nucleotide polymorphism of CKLF-like MARVEL transmembrane member 5 ( CMTM5 ) gene rs723840 and the occurrence of high on aspirin platelet reactivity ( HAPR) . Methods:The present study is a case-control study. A total of 210 hospitalized patients in Peking University First Hospital were enrolled. Aspirin response was assessed by 0. 5 g/L arachidonic acid (AA)-induced platelet aggregation ratio (PR), and ≥3/4 quartile of PR of the population was defined as HAPR. Accordingly all the enrolled 210 coronary artery diseases ( CAD) patients were divided into HAPR group and No-HAPR group. The genotypes were determined by poly-merase chain reaction ( PCR) and sequencing analysis for rs723840 of CMTM5 gene. Results:The geno-type frequencies in rs723840 C>T of CMTM5 gene conformed well to the Hardy-Weinberg equilibrium in both HAPR group and No-HAPR group. Between the two groups, the genotypes frequencies in HAPR and No-HAPR groups were 48 . 4%, 51 . 6%, 0 . 0% and 73 . 7%, 22 . 9%, 0 . 034%, respectively ( P=0. 004). The C, T allele frequencies were significantly different in the two groups (P =0. 031,OR =0 . 501 , 95%CI:0 . 264-0 . 947 ) . Conclusion:Our study finds a significant correlation between CMTM5 gene rs723840 polymorphism and high on aspirin platelet reactivity.关键词
血小板聚集/CMTM5/多态性,单核苷酸/阿司匹林Key words
Platelet aggregation/CMTM5/Polymorphism/single nucleotide/Aspirin分类
医药卫生引用本文复制引用
刘滕飞,张婧薇,陈夏欢,冯雪茹,柏中胜,刘梅林..CMTM5基因rs723840单核苷酸多态性与阿司匹林治疗下血小板高反应性的相关性研究[J].北京大学学报（医学版）,2015,47(6):905-909,5.基金项目
国家国际科技合作专项项目(2013DFA30860)资助Supported by the International Science&Technology Cooperation Projects of Chi-na (2013DFA30860) （2013DFA30860）
