广西医学2015，Vol.37Issue(10)：1393-1396,4.DOI:10.11675/j.issn.0253-4304.2015.10.05
小剂量地西他滨联合异基因造血干细胞分次输注治疗老年骨髓增生异常综合征转急性髓性白血病2例报告
Low-dose decitabine combined with fractional allogeneic hematopoietic stem cell transfusion for treatment of elderly patients with acute myeloid leukemia transformed from myelodysplastic syndrome:a report of 2 cases
摘要
Abstract
Objective To explore the efficay of low-dose decitabine combined with fractional allogeneic hematopoietic stem cell transfusion( micro transplantation) for treatment of elderly patients with acute myeloid leukemia transformed from myelodysplastic syndrome ( MDS-AML) .Methods Two patients diagnosed as MDS-AML were treated with chemotherapy regimen of low-dose decitabine or decitabine combined with CAG(cytosine arabinoside+aclacinomycin) and micro transplantation.The donors were children of patients with human leukocyte antigen semi-matched.Peripheral blood stem cells from the donors were mobilized with granulocyte colony-stimulating factor and then collected. Patients transfused PBSC about 36 hours after the chemotherapy finished.The disease status,platelet levels,survival timeand side effects were observed.Re sults Two cases did not achieve complete response.The survival times of Case 1 and Case 2 were 2 months and 4 months respectively. The platelet level in Case 1 increased remarkably after treatment,and reached to the maximal level of 59 ×109/L.No platelet transfusion was observed in Case 1.In Case 2,the interval of platelet transfusion was prolonged,and the patient was gradually independent on platelet transfusions. No graft-versus-host disease occurred in the two patients.Conclusion For elderly patients with MDS-AML,low-dose decitabine combined with micro transplantation can not cure the disease,but can prolong the survival time,increase the level of platelet and improve the quality of life.关键词
骨髓增生异常综合征/急性髓性白血病/异基因造血干细胞/分次输注/地西他滨/血小板/老年人Key words
Myelodysplastic syndrome/Acute myeloid leukemia/Allogeneic hematopoietic stem cell/Fractional transfusion/Decitabine/Platlet/Elderly分类
医药卫生引用本文复制引用
李云双,陈永升,聂伟业,黄琴,孔祥敬,尹晓林..小剂量地西他滨联合异基因造血干细胞分次输注治疗老年骨髓增生异常综合征转急性髓性白血病2例报告[J].广西医学,2015,37(10):1393-1396,4.基金项目
广西科技攻关计划项目(桂科攻1355005-2-1) （桂科攻1355005-2-1）
广西医药卫生科研课题(Z2014357) （Z2014357）
