摘要
Abstract
Objective To investigate the clinical values of combined detection of serumα‐fetoprotein (AFP) ,α‐L‐fucosidase (AFU ) ,glypican‐3 (GPC3) and Golgi protein 73 (GP73) for the diagnosis of primary hepatic carcinoma (PHC) .Methods The serum levels of AFP ,AFU ,GPC3 and GP73 of PHC patients (n=65 ,PHC group) ,liver cir‐rhosis (LC) patients (n=61 ,LC group) ,and healthy control (n=60 ,normal control group) were respectively detec‐ted ,and the results were analyzed .Results Serum levels of AFP ,AFU ,GPC3 and GP73 in PHC group were signifi‐cantly higher than those in the LC group and normal control group (P< 0 .05) .Comparing with normal control group ,the levels of AFP ,AFU ,GPC3 and GP73 significantly increased in LC group (P<0 .05) .Furthermore ,the sensitivities of AFP ,AFU ,GPC3 and GP73 in the diagnosis of PHC were 69 .23% -78 .46% ,and the accuracies were 81 .72% -84 .95% .The sensitivity and accuracy of combined detection of four markers were up to 95 .38% and 87 .63% respectively ,which were higher than those of single detection .Conclusion Combined detection of serum AFP ,AFU ,GPC3 and GP73 could improve the diagnostic rate of PHC ,especially contribute to the diagnosis of low‐AFP PHC .关键词
甲胎蛋白/α-L-岩藻糖苷酶/磷脂酰肌醇蛋白聚糖3/高尔基体蛋白73/原发性肝癌Key words
α-fetoprotein/α-L-fucosidase/glypican-3/Golgi protein 73/primary hepatic carcinoma
