武警医学2015，Vol.26Issue(12)：1206-1209,4.
e抗原阳性慢性乙型肝炎替比夫定初治的抗病毒疗效
Efficacy and Follow-up of changes in renal function of telbivudine in treatment for pa-tients with HBeAg positive chronic hepatitis B
摘要
Abstract
Objective To evaluate the efficacy and changes in renal function of telbivudine for patients with HBeAg positive chronic hepatitis B(CHB).Methods 30 patients were randomized into telbivudine (LDT) monotherapy group(10 patients),telbivudi-ne plus adefovir(LDT+ADV) combination therapy group (10 patients), and lamivudine plus adefovir (LAM+ADV) combination therapy group(10 patients) for 96 weeks.Serum ALT normalization rate ,rate of undetectable HBV-DNA, HBeAg/anti-HBe seroconve-rsion rate,glomerular filtration rate(GFR) were detected at 12,24,48,72,96weeks ,respectively.Results The virological response rates in the three groups were 100%at weeks 48.LDT monotherapy group first exhibited biochemical response .After 48 weeks ,bio-chemical response in the three group reached 100%.Serological response in LDT monotherapy group ( 50%) was significantly higher than in telbivudine plus adefovir combination therapy group (40%) and lamivudine plus adefovir combination therapy group (0%) at 72 weeks.After 96 weeks,GFR in Telbivudine monotherapy group (112.26 ±2.86)ml/(min· 1.73 m2) was significantly higher than baseline;GFR in telbivudine plus adefovir combination therapy group (100.65 ±2.61) ml/( min· 1.73 m2 ) gradually increased from baseline;and unchanged in lamivudine plus adefovir combination therapy group ( 92.03 ±2.08 ) ml/( min · 1.73 m2 ). Conclusions Telbivudine can a potently and rapidly inhibit HBV DNA replication ,and is efficient in e antigen seroconversion rate . Telbivudine monotherapy or combined with adefovir can significantly improve the patients ' glomerular filtration rate , and thus improve renal function .关键词
慢性乙型病毒性肝炎/药物疗法/替比夫定/肾小球滤过率Key words
chronic hepatitis B virus/drug therapy/telbivudine/eGFR分类
临床医学引用本文复制引用
张金龙,莫国生,刘芙蓉,揭中华,黄志刚..e抗原阳性慢性乙型肝炎替比夫定初治的抗病毒疗效[J].武警医学,2015,26(12):1206-1209,4.基金项目
嘉兴市科技工作专项计划(2014AY21057) （2014AY21057）
