武警医学2015，Vol.26Issue(12)：1210-1212,3.
血清血管内皮生长因子对 POEMS综合征的早期诊断
Detection of serum VEGF is useful for early diagnosis of POEMS syndrome
马丽娜 1于生元 1刘若卓 1付希涛2
作者信息
- 1. 100853 北京,解放军总医院神经内科
- 2. 261500,山东省高密市精神卫生中心
- 折叠
摘要
Abstract
Objective To study the significance of serum VEGF ( vascular endothelial growth factor ) in the differential diag-nosis between POEMS syndrome and peripheral neuropathy , and the value of detection of VEGF in the early diagnosis of POEMS syn-drome.Methods 30 patients were collected in PLA General Hospital from June 2012 to June 2014.18 patients were diagnosed as having POEMS syndrome in the study group and 12 patients diagnosed as having peripheral neuropathy in as the control group .All of them underwent the detection of serum VEGF levels .Results The data displayed that the mean concentration of VEGF in POEMS syndrome group, (687.85 ±179.07) pg/ml (4.8 times of normal value ), was higher than that in the control group ,(301.07 ± 112.53)pg/l (2.1 times of normal value); there was a statistically significant difference between the two groups (t=5.783, P<0.01).The diagnostic area under curve (AUC) was 0.970, cut-off value was 409.33 pg/ml, sensitivity was 1.000, specificity was 0.800, and accuracy was 0.968 respectively.Conclusions VEGF is a very important serological marker of POEMS syndrome .It is helpful for the differential diagnosis of POEMS syndrome and other peripheral neuropathy .The elevated level of serum VEGF value may be meaningful for the diagnosis of the disease , the high VEGF value supports the diagnosis of POEMS syndrome .关键词
POEMS综合征/血管内皮生长因子/周围神经病Key words
POEMS syndrome/vascular endothelial growth factor/peripheral neuropathy分类
临床医学引用本文复制引用
马丽娜,于生元,刘若卓,付希涛..血清血管内皮生长因子对 POEMS综合征的早期诊断[J].武警医学,2015,26(12):1210-1212,3.
