中国组织工程研究Issue(45)：7362-7368,7.DOI:10.3969/j.issn.2095-4344.2015.45.026
间充质干细胞在炎症免疫调节中的作用及应用进展
Mesenchymal stem cells in the inflammatory immunomodulation
摘要
Abstract
BACKGROUND:Studies have shown that the main functions of mesenchymal stem cels include direct participation in wound healing, growth factor secretion, promoting angiogenesis, immune regulation and inflammation, anti-oxidative stress, which can be used to treat a variety of acute and chronic diseases. OBJECTIVE:To review advances in mesenchymal stem cels in the inflammatory immunomodulation. METHODS: A computer-based search of Wanfang, CNKI and PubMed databases was performed for articles concerning advances in mesenchymal stem cels in the inflammatory immunomodulation published from January 2005 to August 2015. The search terms were “stem cels, mesenchymal stem cels, immune regulation, inflammation, immune cels, inflammatory factors, treatment” in Chinese and English, respectively. Finaly, 40 articles were included in result analysis. RESULTS AND CONCLUSION:Because of their immunomodulation and muti-directional differentiation, mesenchymal stem cels garner increasing attentions. In addition, mesenchymal stem cels can be harvested from different tissues and have goodin vitroamplification capability, which have a broad prospect in the clinical use, including tissue repair and anti-inflammation. As the most promising cels used clinicaly, mesenchymal stem cels show their superiority in the treatment of many diseases, especialy in inflammations induced by immune modulation imbalance. We believe that mesenchymal stem cels wil play an important role in the future cel biotherapy.关键词
干细胞/移植/间充质干细胞/免疫调节/炎症/免疫细胞/炎症因子/治疗/国家自然科学基金Key words
Mesenchymal Stem Cel Transplantation/Immunomodulation/Inflammasomes/Tissue Engineering分类
医药卫生引用本文复制引用
郑盛,杨涓,唐映梅..间充质干细胞在炎症免疫调节中的作用及应用进展[J].中国组织工程研究,2015,(45):7362-7368,7.基金项目
国家自然科学基金(81360072)；云南省自然科学基金(2012FD095)；云南省教育厅科研基金重点项目(2014Z125)；云南省临床重点专科建设项目(云卫医发〔2015〕18号)@@@@the National Natural Science Foundation of China, No.81360072 （81360072）
the Natural Science Foundation of Yunnan Province, No.2012FD095 （）
the Key Research Fund of Department of Education for Yunnan Province, No.2014Z125 （）
the Key Clinical Construction Project of Yunnan Province, No.2015(18) （18）
