中国组织工程研究Issue(46)：7498-7503,6.DOI:10.3969/j.issn.2095-4344.2015.46.022
Notch信号通路调控下的血管形成
Regulation of angiogenesis by Notch signaling
摘要
Abstract
BACKGROUND:The Notch signaling pathway is evolutionarily highly conserved and mediated by cel-cel interactions, which is widely involved in cel differentiation, proliferation and apoptosis. This critical transduction system participates in coordinating various functions of vascular endothelial cels, thus playing a vital role in the formation and remodeling of vascular network. OBJECTIVE: To elucidate the components of Notch signaling pathway and its impact on angiogenesis. METHODS: A computer-based online search of PubMed and CBM databases was performed. High-quality articles related to mechanism of angiogenesis regulated by Notch signaling were included, and repetitive studies were excluded. RESULTS AND CONCLUSION:Totaly 31 literatures were selectively included in this review. Angiogenesis is a complicated and muti-stage biological event and has been delicately regulated. Notch signaling participates in the regulation of every stage of angiogenesis directly or indirectly via the crosstalk with vascular endothelial growth factor, BMP-SMAD signaling and extracelular matrix molecules. Furthermore, consistent output of Notch signaling is essential for maintaining the stability and integrity of adult vascular system. This review wil thoroughly clarify the latest progress on angiogenesis regulated by Notch signaling and provide theoretical basis and a potential target for designing therapeutic methods against vascular disease.关键词
组织构建/组织工程/Notch信号通路/血管形成/调控机制/国家自然科学基金分类
医药卫生引用本文复制引用
王拯,张莛蔚,韩向龙..Notch信号通路调控下的血管形成[J].中国组织工程研究,2015,(46):7498-7503,6.基金项目
国家自然科学基金(81371172)@@@@the National Natural Science Foundation of China, No.81371172 （81371172）
