中国组织工程研究Issue(46)：7523-7528,6.DOI:10.3969/j.issn.2095-4344.2015.46.026
SonicHedgehog信号通路在胚胎发育及神经修复中的现状与进展
Role of Sonic Hedgehog signal pathway in embryogenesis and neural regeneration
王苏平 1吴晓君 2闫旭 2赵红1
作者信息
- 1. 大连市中心医院神经内一科，辽宁省大连市 116033
- 2. 大连医科大学，辽宁省大连市 116044
- 折叠
摘要
Abstract
BACKGROUND:Many studies have showed that Sonic Hedgehog (Shh) signal pathway regulates the proliferation and differentiation of nerve cels, axon guidance and neural regeneration after brain injury. OBJECTIVE:To summarize the role of Shh signal pathway in embryonic development and post-natal nerve repair. METHODS:A computer-based retrieval was performed by the first author in PubMed and CNKI database to search related papers published from January 1980 to July 2015 using the keywords of “Shh signal pathway, embryogenesis, neural regeneration” in English and Chinese, respectively. Articles related to Shh signal pathway in embryonic cels differentiation, tissue development, post-natal neural regeneration, axon migration and tumor formation. A total of 38 relevant literatures were retrieved. RESULTS AND CONCLUSION: Recently, Shh signal pathway has become an issue of concern because this signal pathway is closely related with neural regeneration after brain injury. Shh is widely expressed in Hedgehog (Hh) family and plays a crucial role in embryogenesis and organogenesis. Shh is wel known to contribute to the patterning of neural tube system, regulate the proliferation and migration of progenitor cels, and control axonal growth and guidance. In addition, Shh is closely related to tumor formation. Studies have shown that Shh can reduce infarct volume and improve behavior prognosis of stroke rats.关键词
组织构建/组织工程/胚胎发育/Shh/神经修复/细胞增殖/肿瘤/轴突/迁移导向/血管再生分类
医药卫生引用本文复制引用
王苏平,吴晓君,闫旭,赵红..SonicHedgehog信号通路在胚胎发育及神经修复中的现状与进展[J].中国组织工程研究,2015,(46):7523-7528,6.
