现代医药卫生Issue(24)：3689-3691,3693,4.DOI:10.3969/j.issn.1009-5519.2015.24.001
Ezrin和P53在结直肠癌中的表达及临床病理意义
Expression and clinicopathologic significance of Ezrin and P53 in colorectal carcinoma
摘要
Abstract
Objective To study the expression levels of Ezrin and P53 in colorectal carcinoma and their clinicopathologic al significance. Methods The tissue microarray and immunohistochemical staining technology were used to detect the expression of Ezrin and P53 in 109 cases of colorectal carcinoma tissues. The correlation between Ezrin and P53 expressions and their relation with the clinicopathological characteristic of colorectal carcinoma were analyzed by using the statistical method. Results The Ezrin protein was highly expressed in the colorectal carcinoma tissues ,the positive expression rate in the TNM stageⅢ,Ⅳgroup was 89.55%(60/67),which was higher than 23.81%(10/42) in the TNM stageⅠ,Ⅱgroup,the expression positive rate in the low differentiation and non-differentiation group was 94.44%(17/18),which was higher than 58.24%(53/91)in the high and middle differentiation group,the positive rate in the T3,T4 group was 67.31%(70/104),which was higher than 0 (0/5) in the T1,T2 group,the positive rate in the lymph node metastasis group was 89.55%(60/67),which was higher than 23.81%(10/42) in the non-lymph node metastasis group,the differences were statistically significant(P<0.05);its expression had no relation with the sex and age. P53 was highly expressed in the colorectal carcinoma tissues ,the expression positive rate in the TNM stageⅢ, Ⅳgroup was 53.73%(36/67),which was higher than 23.81%(10/42) in the TNM stageⅠ,Ⅱgroup,the positive rate in the low differentiation and non-differentiation group was 72.22%(13/18),which was higher than 36.26%(33/91) in the high and middle differentiation group,the positive rate in the lymph node metastasis group was 53.73%(36/67),which was higher than 23.81%(10/42) in the non-lymph node metastasis group,the differences were statistically significant(P<0.05);its expression had no relation with the sex,age and infiltration degree. The Ezrin expression in the colorectal carcinoma had no relation with P53 (r=0.212,P>0.05). Conclusion Applying the tissue microarray for efficiently detecting clinical tissue samples in large scale is feasible and has the advantages of rapidness,convenience,economy and accuracy. The Ezrin protein may be a useful indicator for predicting the metastasis of colorectal carcinoma;the combined detection of Ezrin and P53 may serve as an effective indicator for judging the prognosis of colorectal carcinoma and screening the metastasis of colorectal carcinoma ,which is conducive to the judgment of colorectal carcinoma prognosis.关键词
结直肠肿瘤/基因,p53/免疫组织化学/Ezrin/组织芯片Key words
Colorectal neoplasms/Genes,p53/Immunohistochemistry/Ezrin/Tissue microarrays引用本文复制引用
王昕炜,丁小英,樊祥山,恽艳,刘元华..Ezrin和P53在结直肠癌中的表达及临床病理意义[J].现代医药卫生,2015,(24):3689-3691,3693,4.基金项目
国家自然科学基金资助项目（81101815）。 （）
