新疆师范大学学报（自然科学版）Issue(4)：22-24,3.
1－（6－溴－3－吡啶基）－1－乙酮的合成研究
A Study on Synthesis of 1-(6-Bromo-Pyridin-3-yl)-Ethanone
曾竟 1喻雅婷 1郭秀秀 1申凰林1
作者信息
- 1. 新疆师范大学 化学化工学院，新疆 乌鲁木齐830054
- 折叠
摘要
Abstract
1-(6-Bromo-pyridin-3-yl)-ethanone was synthesized by using 2,5-dibromo-pyridine as the starting material via two steps reactions of Magnesium halide exchange and nucleophilic substitution, 2-bromo-5-pyridyl magnesium chloride reacted with acetyl chloride smoothly in the presence of 2 mol% CuCl, 2 mol% LiCl and 2 mol% AlCl3 as catalysts at 0oC to room temperature in THF. The total yield of two steps was up to 81%, Ob⁃viously the reagents used were readily available, corresponding procedures were very straightforward and reaction conditions were very mild.关键词
2,5-二溴吡/镁卤交换/亲核取代反应/1-(6-溴-3-吡啶基)-1-乙酮Key words
2,5-dibromopyridine/Magnesium halide exchange/Nucleophilic substitution/1-( 6-Bromo-pyridin-3-yl)-ethanone分类
化学化工引用本文复制引用
曾竟,喻雅婷,郭秀秀,申凰林..1－（6－溴－3－吡啶基）－1－乙酮的合成研究[J].新疆师范大学学报（自然科学版）,2015,(4):22-24,3.
