新医学Issue(12)：808-811,4.DOI:10.3969/j.issn.0253-9802.2015.12.005
HBV与LDH对弥漫性大B细胞淋巴瘤患者化学治疗效果的影响--附144例报告
Effect of HBV/LDH on clinical efficacy of chemotherapy in treatment of diffuse large B cell lymphoma:report of 144 cases
摘要
Abstract
Objective To evaluate the effect of hepatitis B virus(HBV)and lactate dehydrogenase (LDH)upon the clinical efficacy of chemotherapy in the treatment of diffuse large B cell lymphoma (DLBCL). Methods In total,1 44 patients with DLBCL who were treated for the first time were recruited in this study. Among them,66 cases were found to be HBsAg (+)and 77 with high level of LDH (LDH-H).According to HBsAg status (positive /negative)and LDH level (high/normal),all participants were divided into the HBsAg (-) /LDH-N (n =45),HBsAg (-) /LDH-H (n =33),HBsAg (+) /LDH-N (n =22)and HBsAg (+) /LDH-H groups (n =44).All patients received 4-6 cycles of CHOP regime.The effect of HBV and LDH upon the overall efficacy of chemotherapy was assessed.Results The overall efficacious rate of chemo-therapy in DLBCL patients with HBsAg (+)was 62.1 % (41 /66),significantly lower compared with 82.1 %(64 /78)of those with HBsAg (-).The overall efficacious rate of chemotherapy in DLBCL patients with LDH-H was 64.9% (50 /77),considerably lower than 82.1 % (55 /67)of their counterparts with LDH-N (P<0.05).Group comparison revealed that overall efficacious rate of chemotherapy in the HBsAg (-) /LDH-N group was 84.4% (38 /45),78.8% (26 /33)in the HBsAg (-) /LDH-H group,77.3% (1 7 /22)in the HBsAg (+) /LDH-N group and 54.5% (24 /44)in the HBsAg (+) /LDH-H group with statistical significance among four groups (P =0.01 ).Paired comparison indicated that overall efficacious rate in the HBsAg (-) /LDH-N group was significantly higher than that in the HBsAg (+) /LDH-H group (P =0.002).No statistical significance was noted among the other groups.Conclusion Infection of HBV and high level of LDH probably exert a negative and synergetic effect upon the clinical efficacy of chemotherapy in trea-ting DLBCL.关键词
弥漫性大B细胞淋巴瘤/乙型肝炎病毒/乳酸脱氢酶Key words
Diffuse large B cell lymphoma/Hepatitis B virus/Lactate dehydrogenase引用本文复制引用
胡利娟,刘相富,胡小山,周旻..HBV与LDH对弥漫性大B细胞淋巴瘤患者化学治疗效果的影响--附144例报告[J].新医学,2015,(12):808-811,4.基金项目
国家自然科学基金青年项目（81302037）；广州医科大学博士启动基金 （）
