中国医学创新2015，Vol.12Issue(32)：81-83,3.DOI:10.3969/j.issn.1674-4985.2015.32.025
乌司他丁联合地塞米松治疗创伤性肺损伤对患者血清一氧化氮及内皮素的影响
Influence of Ulinastatin in Combination with Dexamethasone on Patients' Serum Nitric Oxide and Endothelin-1 in the Treatment of Traumatic Lung Injury
王庆秀 1刘萃 2王庆亮3
作者信息
- 1. 山东省高密市中医院 山东 高密 261500
- 2. 山东省胶州市人民医院
- 3. 山东省青岛市胶州中心医院
- 折叠
摘要
Abstract
Objective:To investigate the combined effects of Ulinastatin and Dexamethasone on serum levels of nitric oxide(NO) and endothelin-1(ET-1) in patients with traumatic lung injury.Method:52 patients with traumatic lung injury in our hospital from January 2014 to January 2015 were selected and randomly divided into the observation group and the control group,each group had 26 patients.Patients in the control group received extra Dexamethasone on the basis of traditional treatment while patients in the observation group received Ulinastatin on the basis of the control group.Mechanical ventilation rate and incidence rate of acute respiratory distress syndrome(ARDS) were recorded and compared between the two groups.The PA-aDO2,PaO2/FiO2,PaO2 and the levels of NO and ET-1 were analyzed and compared.Result:The mechanical ventilation rate and the incidence rate of ARDS in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After 5 days of treatment,the PaO2 and PaO2/FiO2 of the two groups were all higher than before treatment,the PA-aDO2 and the levels of NO and ET-1 of the two groups were lower than before treatment,the PaO2,PaO2/FiO2 and the levels of NO and ET-1 of the observation group were better than those of the control group,the differences above were all statistically significant(P<0.05). Conclusion:Ulinastatin combined with Dexamethasone in the treatment of traumatic lung injury can significantly improve the treatment effects and patients' oxygenation status,thus reduce the incidence rate of inflammation and the utilization rate of mechanical ventilation.关键词
机械通气/一氧化氮/内皮素-1/乌司他丁/地塞米松Key words
Mechanical ventilation/Nitric oxide/Endothelin-1/Ulinastatin/Dexamethasone引用本文复制引用
王庆秀,刘萃,王庆亮..乌司他丁联合地塞米松治疗创伤性肺损伤对患者血清一氧化氮及内皮素的影响[J].中国医学创新,2015,12(32):81-83,3.
