中国中西医结合影像学杂志2015，Vol.13Issue(6)：593-597,5.DOI:10.3969/j.issn.1672-0512.2015.06.002
透骨消痛颗粒干预早中期兔骨关节炎的影像学观察
Imaging study on osteoarthritis in rabbits treated with Tougu Xiaotong Granule
摘要
Abstract
Object:To investigate the effection of Tougu Xiaotong Granules in early and mid osteoarthritis of rabbits and the application value of imaging technology in OA experiment. Methods:48 New Zealand white rabbits were randomly divided into normal group,model group,Tougu Xiaotong group,and bolus group. All models were based on the improved Hulth. DR,CT,MRI screening technology was taken in 4W,8W,12W,16W after operation,observing the changes of joint space narrowing,subchon-dral bone,osteophytes,arthroedema,cartilage,et al. Results:Model group had more arthroedema each time,early experiments (4 and 8 weeks) could observe subchondral sclerosis,late experiments (12 and 16 weeks) slightly joint space narrowing could be seen. Tougu Xiaotong group of mid-dose and high-dose had lesser arthroedema than model group each time,with cartilage sur-face coarse and subchondral sclerosis and lightest high-dose group lesions in late experiments. The performance of bolus group was between high-and low-dose Tougu Xiaotong group. Conclusion:Tougu Xiaotong Granules can reduce inflammation of OA,de-lay lesion of subchondral bone and recover the cartilage.关键词
骨关节炎/透骨消痛颗粒/磁共振成像/放射摄影术Key words
Osteoarthritis/Tougu Xiaotong Granules/Magnetic resonance imaging/Radiography引用本文复制引用
许亚晔,刘献祥,卢小冬,郑章和,陈文列,林如辉,戚婉,叶秀芳,吴广文,吴追乐..透骨消痛颗粒干预早中期兔骨关节炎的影像学观察[J].中国中西医结合影像学杂志,2015,13(6):593-597,5.基金项目
福建省自然科学基金项目(2014J01356) （2014J01356）
陈可冀中西医结合发展基金项目(CKJ2011004). （CKJ2011004）
