中山大学学报（自然科学版）Issue(6)：1-5,5.DOI:10.13471/j.cnki.acta.snus.2015.06.001
以化橘红为基源的一类新药柚皮苷的临床前研究
The Pre-Clinical Studies of Naringin, An Innovative Drug, Derived from Citri Grandis Exocarpium (Huajuhong)
摘要
Abstract
Naringin is a pharmacologically active compound extracted and purified from Citri Grandis Ex-ocarpium ( Huajuhong) .During the past more than ten years, naringin has been developed into a classⅠinnovative drug to treat cough by our group.The Drug Clinical Trial Approval of naringin was issued by China Food and Drug Administration.As such, this review aims to summarize all of pre-clinical studies of naringin from our laboratory, including pharmacological effects and acting mechanisms, non-clinical pharmacokinetics and toxicological evaluation.关键词
一类新药/柚皮苷/临床前研究/药理作用/药代动力学/毒理学Key words
classⅠnew drug/naringin/pre-clinical research/pharmacological effect/pharmacokinet-ics/toxicology分类
药学引用本文复制引用
李沛波,柳颖,王声,陈妍,苏畅,方思琪,苏薇薇,王永刚,吴忠,彭维,杨翠平,聂怡初,刘孟华,罗钰龙,邹威..以化橘红为基源的一类新药柚皮苷的临床前研究[J].中山大学学报（自然科学版）,2015,(6):1-5,5.基金项目
国家“重大新药创制”科技重大专项资助项目（2011ZX09102－011－03）；国家自然科学基金资助项目 （）
