中山大学学报（自然科学版）Issue(6)：104-110,7.DOI:10.13471/j.cnki.acta.snus.2015.06.019
多糖及多糖衍生物／泊洛沙姆温敏水凝胶的制备及其性能研究
Preparation and Properties of Temperature Sensitive Hydrogels Composed of Polysaccharides and Their Derivatives/Poloxamers
摘要
Abstract
To improve the property of poloxamer hydrogels, temperature sensitive hydrogels were pre-pared from poloxamer and five kinds of polysaccharides as well as their derivatives with different chemical structures in this work.The effect of the chemical structures of polysaccharides and their derivatives on the hydrogel properties was investigated.The result indicated that the polysaccharides and their deriva-tives could form the hydrogels with poloxamer at the temperature (34~37 ℃) near human beings’tem-perature, which is advantageous for the injection application.The amphiphilic polysaccharide derivative/poloxamer hydrogels exhibited higher stabilities, stronger shear thinning behaviours, longer time for relea-sing hydrophobic drug of prednisone.These properties are probably related to the hydrophobic interac-tions between the amphiphilic polysaccharide derivatives and poloxamer.Five kinds of temperature sensi-tive hydrogels all exhibited the property for promoting the growth of osteoplasts, showing the potential ap-plication in the osseous junction’s tissues.关键词
多糖/多糖衍生物/泊洛沙姆/温敏水凝胶/强的松Key words
polysaccharide/polysaccharide derivative/poloxamer/temperature-sensitive hydrogel/prednisone分类
化学引用本文复制引用
胡亦清,康贤通,张黎明,杨立群,赖欣宜,罗嘉浩,龙茜,曾春莲,傅超萍,冯子乐,曲海洪,章戴荣..多糖及多糖衍生物／泊洛沙姆温敏水凝胶的制备及其性能研究[J].中山大学学报（自然科学版）,2015,(6):104-110,7.基金项目
国家自然科学基金资助项目（21244005）；广东省部产学研结合资助项目 （）
