安徽医科大学学报2015，Vol.50Issue(12)：1791-1794,4.
4种血清标志物在类风湿关节炎的诊断、疾病活动度的判断及骨侵蚀的预测的应用价值
Values of four serum markers in the diagnosis, the assessment of disease activity and the prediction of bone erosion of rheumatoid arthritis
摘要
Abstract
Objective To systematically evaluate the values of four serum markers including glucose-6-phosphate isomerase ( GPI ) , rheumatoid factor ( RF ) , anti-keratin antibody ( AKA ) and anti-cyclic citrullinated peptide ( CCP) antibody in the diagnosis, the assessment of disease activity and the prediction of bone erosion of rheumatoid arthritis(RA). Methods The serum samples of 193 patients with RA,158 non-RA rheumatic patients and 98 healthy controls were collected. The expressions of GPI and anti-CCP were measured by ELISA methods. The level of RF was measured by the immune turbidimetric methods; AKA was measured by indirect immunofluorescence methods. Results The positive rates of these four antibodies in RA patients were significantly higher than in non-RA rheumatic patients and healthy controls group(P<0. 05),the combined detection of these four antibodies could obviously improve the sensitivity and the specificity in the diagnosis of RA. The mean levels of GPI ,RF and anti-CCP were significantly higher in RA patients than that of in non-RA rheumatic patients and healthy controls group ( P<0. 05 ) . There were significant differences between the active phase and the inactive phase in the GPI and RF levels(P<0. 05);with the value of the anti-CCP,there was no difference between the active phase and the inactive phase. The levels of GPI and RF in the bone erosion group and the non-bone erosion group had no significant difference;with the value of the anti-CCP,there was obvious difference between the bone erosion group and the non-bone erosion group(P<0. 05). The positive rate of AKA in the active phase and the inactive phase had no differ-ence;while,there was significant difference between the bone erosion group and the non-bone erosion group ( P<0. 05 ) . Conclusion The combined detection of these four antibodies has important clinical significance in the di-agnosis of RA. The serum concentrates of GPI and RF have significantly positive correlation with disease activity of RA. It is valuable to predict the bone erosion of RA, using detection of anti-CCP. The patients with positive AKA may exhibit more bone damage.关键词
GPI/RF/AKA/抗CCP抗体/RA/诊断/疾病活动度/骨侵蚀预测Key words
glucose-6-phosphate isomerase/rheumatoid factor/anti-keratin antibody/anti-cyclic citrullinated pep-tide antibody/rheumatiod arthritis/diagnosis/disease activity/predicting of bone erosion分类
医药卫生引用本文复制引用
张琼,罗以勤,汪元,黄开泉,朱俊..4种血清标志物在类风湿关节炎的诊断、疾病活动度的判断及骨侵蚀的预测的应用价值[J].安徽医科大学学报,2015,50(12):1791-1794,4.基金项目
国家自然科学基金青年基金项目(编号:81302967) （编号:81302967）
