安徽医科大学学报2015，Vol.50Issue(12)：1795-1799,5.
CD44 v6和FOXD3在人胃癌组织中的表达及临床意义
The expression and clinical significance of CD44 v6 and FOXD3 in human gastric carcinoma
摘要
Abstract
Objective To research the expressions of CD44 v6 and FOXD3 protein in human gastric cancer tissue and the relation with the biologic behavior of gastric carcinoma. Methods The expressions of CD44v6 and FOXD3 in human gastric cancer and gastric normal tissue (100 cases of human gastric cancer,40 cases of gastric normal tis-sues and 110 cases of gastric cancer microarray) were detectd by immunohistochemistry Envision two step method. Results The positive expression rate of CD44 v6 in gastric cancer and nomal gastric tissue were respectively 88%and 22. 5% (P<0. 001) in traditional tissue species,which were related with the depth of infiltration, the transfer of lymph gland and clinical stages ( P<0. 001 ) . In the gastric cancer tissue and normal tissue adjacent to carcino-ma, the expression rates of FOXD3 were respectively 22% and 90% (P<0. 001),which were also related with the depth of infiltration, the transfer of lymph gland and clinical stages (P<0. 001). The relation between the expres-sions of CD44v6 and FOXD3 was significantly nagtively correlated (rs= -0. 276,P<0. 01). The expression results of CD44 v6 and FOXD3 in gastric cancer tissue microarray were similar with that in the traditional pathologic sec-tion. Conclusion As a stem cell,it is possible that FOXD3 serves as a marker of gastric stem cells concerning its relation with the biologic behavior of gastric cancer and its correlation with FOXD3 .关键词
CD44v6/FOXD3/胃癌/干细胞/免疫组织化学/组织芯片Key words
CD44 v6/FOXD3/gastric cancer/stem cell/immunohistochemistry/tissue microarray分类
医药卫生引用本文复制引用
陈勇,张红,吴梦婕,姚元春,杨春香,秦蓉..CD44 v6和FOXD3在人胃癌组织中的表达及临床意义[J].安徽医科大学学报,2015,50(12):1795-1799,5.基金项目
安徽省自然科学基金(编号:090413118) （编号:090413118）
