国际妇产科学杂志2015，Vol.42Issue(6)：630-633,721,5.
maspin和p53在妊娠滋养细胞疾病中的表达及临床意义
Expression of maspin and p53 in Gestational Trophoblastic Disease and Its Clinical Significance
摘要
Abstract
Objective:To explore the expressions of maspin and p53 in gestational trophoblastic disease, and their roles in the development of hydatidiform mole. Methods:The expressions of maspin and p53 were detected by immunohistochemistry (PV9000) in 22 cases of normal early pregnancies, 82 cases of hydatidiform moles (35 cases were followed up to occur malignant transformation) and 11 cases of gestational trophoblastic tumors. Results:Hydatidiform mole without malignant transformation group and normal early pregnancy group, hydatidiform mole with malignant group and hydatidiform mole without malignant transformation group, the positive expression rate of maspin was significantly lower, but the positive expression rate of p53 was significantly higher, the difference was statistically significant (P<0.05). In moles with malignant high risk factors such asβ-hCG>105 U/L, uterus volume>gestation weeks, ovary lutein cyst>6 cm, the expression of maspin was lower than those groups such asβ-hCG≤105 U/L,uterus volume≤gestation weeks, ovary lutein cyst≤6 cm (P<0.05), while the expression of p53 was higher in moles with malignant high risk factors such as β-hCG>105 U/L,ovary lutein cyst >6 cm compared with those without risk factors groups (P<0.05). Maspin expression was correlated with p53 (P<0.05). In 35 cases of malignant moles the expression of maspin in FIGO prognostic score≥7 was lower than that in FIGO prognostic score<7 (P<0.05). The expression of p53 in anatomy stagingⅢgroup was higher than that in anatomy stagingⅠ-Ⅱgroup (P<0.05). Conclusions:Decreased expression of maspin and high expression of p53 may be early events in the malignant transformation of hydatidiform mole. It is suggested that the joint detection of both proteins provide certain reference value in predicting hydatidiform mole malignant transformation and prognostic evaluation of gestational trophoblastic disease.关键词
maspin/p53/葡萄胎/绒毛膜癌/免疫组织化学Key words
maspin/p53/Hydatidiform mole/Choriocarcinoma/Immunohistochemistry引用本文复制引用
吴齐斌,郑秀,吴荔香,宋一一,孙蓬明..maspin和p53在妊娠滋养细胞疾病中的表达及临床意义[J].国际妇产科学杂志,2015,42(6):630-633,721,5.基金项目
福建省人事厅2007年度留学人员科技活动项目 （）
