解放军医药杂志2015，Vol.27Issue(12)：32-35,4.DOI:10.3969/j.issn.2095-140X.2015.12.007
IκB-α、MMP-9在食管癌中的表达及其生物学意义
Expressions of IκB-αand MMP-9 in Esophageal Cancer and Its Biological Significance
刘亮 1王莉 1倪晓辰 1武中林 1王光大 1赵阳 1左静 1王静 1左连富1
作者信息
- 1. 050011 石家庄,河北医科大学第四医院肿瘤研究所流式细胞室
- 折叠
摘要
Abstract
Objective To detect the expressions of inhibitor of NF-κB α ( IκB-α) and matrix metalloprotein-9 (MMP-9) protein of nuclear factor kappa B (NF-κB) in different esophageal lesion tissues and to explore the relationship between IκB-α and MMP-9 expressions and pathogenesy, development and metastasis of esophageal cancer. Methods The IκB-α and MMP-9 protein expressions in esophagus squamous cell carcinoma, esophageal atypical hyperplasia and normal esophageal tunica mucosa tissues were detected using immunohistochemistry method;the relationship between the IκB-α and MMP-9 protein expressions in tissues of esophagus squamous cell carcinoma and different clinicopathological features were analyzed as well as the relationship between IκB-αand MMP-9 expressions in tissues of esophagus squamous cell carcinoma. Results The IκB-α protein expression in tissues of esophagus squamous cell carcinoma (80. 0%) was significantly higher than 52. 3% in tissues of esophageal atypical hyperplasia and 8. 3% in normal esophageal tissues, and the differences were statistically significant ( P<0. 05 ) , and the differences were related to lymph node metastasis and invasion depth. The MMP-9 protein expression in tissues of esophagus squamous cell carcinoma (73. 3%) was sig-nificantly higher than 71. 4% in tissues of esophageal atypical hyperplasia and 16. 7% in normal esophageal tissues, and the differences were statistically significant ( P<0. 05 ) , and the differences were related to cell differentiation degree, lymph node metastasis and invasion depth. IκB-α and MMP-9 protein expressions in esophageal cancer tissues did not have significant correlation (P>0. 05). Conclusion The abnormal expressions of IκB-αand MMP-9 protein in esopha-geal cancer is involved in the invasion and metastasis of esophageal cancer.关键词
食管鳞状细胞癌/免疫组织化学/基质金属蛋白酶/浸润,转移Key words
Esophagus squamous cell carcinoma/immunohistochemistry/Matrix metalloproteinases/Invasion/metastasis分类
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刘亮,王莉,倪晓辰,武中林,王光大,赵阳,左静,王静,左连富..IκB-α、MMP-9在食管癌中的表达及其生物学意义[J].解放军医药杂志,2015,27(12):32-35,4.
