摘要
Abstract
Objective To investigate the expression characteristics of thyroid transcription factor-1 (TTF-1) in non-small-cell lung carcinoma ( NSCLC) and its relationship with the clinicopathological features of the patients. Meth-ods Specimens of 167 patients with NSCLC confirmed by pathological results after thoracic surgery were collected, and immunohistochemical method was used to detect TTF-1 protein expressions, and then its relationship with the clinicopath-ological features of the patients with NSCLC was analyzed. Results Among the 167 specimens, there were 95 cases (56. 89%) of positive expression TTF-1. TTF-1 protein was highly expressed in TNM staging (stage Ⅲ + Ⅳ), lymph node metastasis and adenocarcinoma patients, and the positive expression rates were 70. 73%, 75. 36% and 83. 00% re-spectively, and positive expression rates were 43. 53% in TNM staging (stage Ⅰ + Ⅱ), 43. 88% in non-lymph node me-tastasis and 17. 91% in squamous cell carcinoma patients, and the differences were statistically significant (P<0. 01). TTF-1 protein expressions in patients with NSCLC showed no significant relations with age, gender, degree of differentia-tion ( P >0. 05 ) . Conclusion The positive expression of TTF-1 protein in non-small-cell lung carcinoma tissues is high, and it has certain relationship with TNM staging, pathological type and lymph node metastasis.关键词
甲状腺转录因子-1蛋白/癌,非小细胞肺/表达特点/临床病理特征Key words
Thyroid transcription factor-1 protein/Carcinoma/non-small-cell lung/Expression feature/Clini-copathological features分类
医药卫生
