哈尔滨商业大学学报（自然科学版）2015，Vol.31Issue(6)：671-674,4.
双黄连粉针中间体与制剂UPLC-MS指纹图谱相关性
Correlational research of UPLC-MS fingerprinting system of intermediates and preparation of SHL powder injection
摘要
Abstract
To establish SHL powder injection intermediates UPLC-MS fingerprinting.Using ACQUITY UPLCTM BEH C18 Column (1.7μm, 2.1 ×50 mm, Waters Corp, Milford USA) as column, mobile phase of acetonitrile and 0.1% formic acid, gradient elution, the flow rate was 0.3 mL/min, and the column temperature was 40℃.A total of 13 batches of UP-LC fingerprint pattern of SHL powder injection intermediates were established.There were 26 common peaks in the characteristic maps.Three main peaks were identified with reference substances for comparison, and each peak has a better separation.A cluster analysis for characteristic spectra of 13 batches SHL intermediate was done, and the"Chinese medicine chromatographic fingerprint evaluation system (2004A Edition)" was used to evaluate their quality.The method was rapid, efficient and can be used for quality control of SHL injection intermediates, while between FPP and had a good correlation.关键词
双黄连粉针中间体/指纹图谱/UPLC-MS/相关性Key words
SHL powder for intermediates/fingerprints/UPLC-MS/correlation分类
医药卫生引用本文复制引用
石朗,顾媛媛,焦丁宁,苏德龙,王英昕,董培良,陈大忠..双黄连粉针中间体与制剂UPLC-MS指纹图谱相关性[J].哈尔滨商业大学学报（自然科学版）,2015,31(6):671-674,4.基金项目
黑龙江省应用技术研究与开发计划项目(GC13C109) （GC13C109）
"重大新药创制"科技重大专项-双黄连粉针剂技术改造(2011ZX09201 -201-15) （2011ZX09201 -201-15）
