临床神经病学杂志2015，Vol.28Issue(6)：417-421,5.
HLA-DQB1等位基因多态性与新疆人群重症肌无力的相关性研究
Study of association between HLA-DQB1 allele gene polymorphism and myasthenia gravis in Xinjiang populations
摘要
Abstract
Objective To approach the association between HLA-DQB1 allele gene polymorphism and myasthenia gravis( MG) in Xinjiang populations.Methods The HLA-DQB1 genotypes of the 120 patients with MG and 120 healthy controls came from Xinjiang were determined by sequencing-based typing ( SBT ) method .The frequencies of the DQB1 alleles were conpared between the two groups.Results A total of 14 DQB1 alleles genes were identified .The frequency of the DQB1*05:03 allele gene in MG group was siginificantly higher than that in the healthy control group (OR=2.818,P=0.002), the frequency of DQB1*02:01:01 and DQB1*06:02 allele gene in the MG group were siginificantly lower than those in the healthy control group (OR=0.179,P=0.006;OR=0.511,P<0.001) The frequency of the DQB1*04:01:01、DQB1*05:03 allele gene in Han Chinese MG group were siginificantly higher than those in the healthy control group (OR=4.000,P=0.009;OR=3.077,P=0.006). The frequency of DQB1*02:01:01 and DQB1*06:02 allele gene in the Han Chinese MG group were siginificantly lower than those in control group(OR=0.358,P=0.002;OR=0.207,P<0.001).However, the HLA-DQB1 gene had no difference between Uighur MG patients and the healthy control group .Conclusions MG in Xinjiang populations is associated with HLA-DQB1*05 allele gene, which in the Han Chinese MG group is associated with DQB1*04:01:01.While those patients are absence of the DQB1*06:02 and DQB1*02:01:01,which might play a protective role in Xinjiang populations.关键词
重症肌无力/HLA-DQB1/基因多态性Key words
myasthenia gravis/HLA-DQB1/polymorphism分类
医药卫生引用本文复制引用
王晓蓓,张小宁,韩登峰,吐尔洪·吐尔逊,赵学飞..HLA-DQB1等位基因多态性与新疆人群重症肌无力的相关性研究[J].临床神经病学杂志,2015,28(6):417-421,5.基金项目
重症肌无力临床亚型及相关抗体与 HLA -DQB1、HLA-DR基因的相关性研究(2015211C045) （2015211C045）
