摘要
Abstract
OBJECTIVE:To observe therapeutic efficacy and safety of Compound digestive enzyme capsule in the treatment of dyspepsia. METHODS:154 patients with dyspepsia were selected and randomly divided into observation group and control group, with 77 patients in each group. Control group received routine treatment,Polyzyme tablet 600 mg,tid,30 min after meal;observa-tion group was additionally given Compound digestive enzyme capsule 600 mg,tid,30 min after meal. Treatment course of 2 groups lasted for 2 weeks. The improvement of dyspepsia,clinical efficacy,clinical manifestation score,improvement duration and ADR were observed in 2 groups after treatment. RESULTS:The total effective rate of observation group(89.61%)was significant-ly higher than that of control group(74.03%),with statistical significance(P<0.05). After treatment,the improvement of abdomi-nal distension,early satiety,belching,epigastric discomfort,epigastrium pain,epigastric burning sensation,nausea,vomiting and other clinical digestive symptoms in observation group were significantly better than control group,while clinical symptom score and improvement duration were significantly lower or shorter then control group,with statistical significance(P<0.05). There was no statistically significant difference in the incidence of ADR between observation group (3.90%) and control group (5.19%), with statistical significance (P>0.05). CONCLUSIONS:Compound digestive enzymes capsule has good effect on dyspepsia with less ADR.关键词
复方消化酶胶囊/消化不良/疗效/安全性Key words
Compound digestive enzyme capsule/Dyspepsia/Therapeutic efficacy/Safety分类
医药卫生
