摘要
Abstract
OBJECTIVE:To investigate the efficacy of of desmopressin combined with oxybutynin in treatment of children with monosymptomatic nocturnal enuresis.METHODS:206 children with monosymptomatic nocturnal enuresis admitted into Children's Hospital of Kaifeng City from Jan.2013 to Dec.2014 were divided into two groups via the random number table.100 μg group with 101 cases were given 100 μg desmopressin treatment,200 μg group with 105 cases were treated with 200 μg desmopressin treatment,the treatment course was 2 weeks.The children only received desmopressin with a failure were divided into observation group and control group via the random number table,61 cases in observation group were given desmopressin combined with 5 mg oxybutynin,while the control group received desmopressin combined with placebo,the treatment course last for 4 weeks,the bladder capacity and wall thickness index of children were detected.RESULTS: The complete response rate of children in 100 μg group and 200 μg group were respectively 34.65% ( 35/101 ) and 36.19%( 38/105 ),with statistically significant difference (P>0.05).The complete response rate,partial response rate of observation group were significantly higher than that of control group [ 21.31%( 13/61 ) VS 5.08%( 3/59 ),24.59%( 15/61 ) VS 13.56 ( 8/59 ) ],with significant difference ( OR=0.24,95%CI=0.10-0.56,P<0.01).And the significant low level of BVWI and average bladder capacity were observed in children from observation group with complete response,the nocturnal urine volume of complete response was significantly higher than that of partial response and no response,the difference was statistically significant ( P <0.01 ).CONCLUSIONS: The efficacy of desmopressin combined with oxybutynin in treatment of children with monosymptomatic nocturnal enuresis is significant,which is worthy of clinical promotion.关键词
去氨加压素/单症状性夜间遗尿症/奥昔布宁Key words
Desmopressin/Monosymptomatic nocturnal enuresis/Oxybutynin分类
医药卫生
