中国医院用药评价与分析2015，Vol.15Issue(12)：1613-1616,4.DOI:10.14009/j.issn.1672-2124.2015.12.017
癫痫患者丙戊酸血清浓度监测及与临床疗效的关联性分析
Analysis of Correlation between Monitoring of Serum Concentration of Valproic Acid and Clinical Efficacy in Patients with Epilepsy
陈玲 1苗苗 1刘俊1
作者信息
- 1. 皖南医学院弋矶山医院药剂科,安徽芜湖 241001
- 折叠
摘要
Abstract
OBJECTIVE:To study the monitoring results of the serum concentration of valproic acid ( VPA ) in patients with epilepsy,and to provide reference for the rational use of drug in clinic.METHODS: The serum concentration of VPA was determined by the fluorescence polarization immunoassay;the effects of gender,age and drug combination on the serum concentration of VPA,as well as the correlation between the serum concentration of VPA and clinic efficacy were analyzed.RESULTS:Gender differences might not be the influence factors of serum concentrations of valproic acid.The serum concentration of VPA and the patients'age showed the negative correlation.And the serum concentration of VPA in 0-18 year-old group were(66.12 ±28.08) μg/ml,which were significantly higher than that in 19-59 year-old group (57.53 ±29.85) μg/ml and over 60 year-old group (51.72 ±22.60) μg/ml,with statistically significant difference ( P<0.05 ); and there were also significant difference in the distributions of different ranges of concentration (P<0.05).There were obvious correlation between serum concentration of VPA and efficacy.The serum concentration of VPA in combination therapy group was (41.35 ±19.89) μg/ml,significantly higher than that in single therapy group (65.93 ±26.58) μg/ml,and there were significant difference in the distributions of different ranges of concentration in two groups ( P<0.05 ).Among 461 cases with monitoring of serum concentration of VPA,266 cases (57.70%) were in 50~100μg/ml,and 152 cases (32.97%) and 43 cases (9.33%) were respectively <50 μg/ml and >100μg/ml.The effective rate of epilepsy treatment in range of 50~100μg/ml of serum concentration of VPA was 90.60%(241/266),significantly higher than that in range of <50μg/ml 33.55%(51/152)and >100μg/ml 76.74%(33/43),with statistically significant difference ( P <0.05 ); which showed that there were significant correlation between the serum concentration of VPA and clinic efficacy.CONCLUSIONS:Monitoring of the serum concentration of VPA can provide objective evidence for formulating individualized therapeutic regimen in patients with epilepsy.关键词
丙戊酸/血清浓度/治疗药物监测/个体化用药/癫痫Key words
Valproic acid/Serum concentration/Monitoring of therapeutic drug/Individualized medication/Epilepsy分类
药学引用本文复制引用
陈玲,苗苗,刘俊..癫痫患者丙戊酸血清浓度监测及与临床疗效的关联性分析[J].中国医院用药评价与分析,2015,15(12):1613-1616,4.
