摘要
Abstract
Objective To analyze the clinical distribution and change of antimicrobial resistance of Pseudomonas aeruginosa and observe the use of clinical antibiotics so as to provide guidance for the rational use of antibiotics and the effective control of infection. Methods Retrospective review on distribution and antimicrobial resistance of the 859 strains Pseudomonas aeruginosa collected from January 2012 to December 2014, the use of corresponding antibiotics was analyzed in terms of DDDs and use intensity. Results A total of 859 P. aeruginosa strains were isolated, mostly from sputum specimens(583 strains, 67.9%) and burn specimens (110 strains, 12.8%). The isolation rate of multi-drug resistant P. aeruginosa (MDRPA) was 19.0%and the isolation rate of pan-drug resistant P. aeruginosa (PDRPA) was 5.5%. According to the resistance monitoring results, the antimicrobial resistance rate of P. aeruginosa to amikacin, piperacillin-tazobactam and gentamicin were less than 10.0%, the antimicrobial resistance rate to meropenem, piperacillin, ciprofloxacin, cefepime, ceftazidime, imipenem, levofloxacin and aztreonam varied at 12.4%-23.9%. The DDDs showed that the use intensity of cefuroxime, cefoperazone-sulbactam and levofloxacin ranked in the top 4 for three consecutive years, while that of meropenem and imipenem stayed a relatively low level, the use intensity of aztre-onam reduced substantially. Conclusion P. aeruginosa was the main cause of respiratory tract and burn wound infec-tion, the detection rate of showed an upward trend from 2012 to 2014, while the detection rate of multi-drug resistant P. aeruginosa (MDRPA) and pan-drug resistant P. aeruginosa (PDRPA) has declined. The resistance rate of P. aerugi-nosa to commonly used antimicrobial agents was decreased. Therefore, the work of monitoring drug resistance and pro-moting rational application of antibiotics should be strengthened.关键词
铜绿假单胞菌/耐药性/抗菌药物/用药频度/使用强度Key words
Pseudomonas aeruginosa/Antimicrobial resistance/Antibiotics/DDDs/Use intensity分类
临床医学
