中国现代医生2015，Vol.53Issue(35)：99-102,4.
医院感染肠球菌的临床分布及耐药性分析
Clinical distribution and drug resistance analysis of hospital infection en-terococci
摘要
Abstract
Objective To investigate the clinical isolation situation and drug resistance features of enterococcal bacteria in order to provide reference for the clinical rational use of antibacterial agents and infection control. Methods A total of 1220 strains of enterococcal bacteria that induced hospital infection were analyzed retrospectively. Walk Away 96 automated microbial analyzer was used for strain identification and drug sensitive test. MIC was used for screening high-level aminoglycoside resistant strains. WHONET 5.6 was used for data analysis. Results A total of 1220 strains of enterococci were detected, including 675 strains of enterococci faecalis, accounting for 55.3%, and 445 strains of ente-rococci faecium, accounting for 36.5%. Enterococcal bacteria mainly distributed in clinical urine specimens, accounting for 57.5%. The total drug resistance rate of enterococci faecalis was high and the drug resistance rates to penicillin, ampicillin, ciprofloxacin and levofloxacin were all higher than 90%, which were significantly higher than those of the enterococci faecium (<17%). The drug resistance rate of enterococci faecalis to quinupristin/dalfopristin was 100.0%and that of enterococci faecium was 12.6%. For both types of bacteria, no strain resistant to vancomycin was found, but 3 strains of enterococci faecalis were resistant to linezolid. The screening rates of enterococci faecalis for high-level gentamicin drug resistant strains and high-level streptomycin resistant strains were 54.1% and 27.3% respectively while those of enterococci faecium were 58.2% and 56.9% respectively. Conclusion The drug resistance situation of enterococcal bacteria to common antibacterial drugs is not optimistic, and the monitoring of clinical distribution and drug resistance situation of enterococcal bacteria is of important guiding significance to the clinical treatment of entero-coccal bacterial infection.关键词
粪肠球菌/屎肠球菌/抗菌药物/耐药性Key words
Enterococci faecalis/Enterococci faecium/Antimicrobial agents/Drug resistance分类
临床医学引用本文复制引用
江丹英,林雪峰,王兵勇,陈静,应华永..医院感染肠球菌的临床分布及耐药性分析[J].中国现代医生,2015,53(35):99-102,4.基金项目
浙江省公益技术应用研究计划项目(2012C33 023) （2012C33 023）
浙江省温州市医药卫生科学研究项目(2015A17) （2015A17）
