湖南中医药大学学报2016，Vol.36Issue(1)：37-40,4.DOI:10.3969/j.issn.1674-070X.2016.01.008
秦皮甲素两种给药途径在大鼠体内药代动力学研究
Pharmacokinetic Study of Aesculin in Rats of Two Administration Routine in Vivo
摘要
Abstract
Objective To study the pharmacokinetics of aesculin in rats of two administration routine in vivo. Methods The rats were given aesculin by intragastric administration (ip) and intraperitoneal injection (ig) with a dosage of 100 mg/kg. The plasma at different time points was collected. The concentration of aesculin in rats' plasma was determined by HPLC and its pharmacokinetic parameters were calculated. Results The pharmacokinetics of aesculin by ig and ip routine met first-order and mono-compartment model, the critical parameters shown as below, respectively: AUC0→∞=(3.76±0.44) mg·h/L, (149.64±20.71) mg·h/L; Ke=(0.83±0.22)/h, (1.38±0.13)/h; Cmax=(2.63±0.60) mg/L, (164.37±16.94) mg/L;Tmax=(0.17±0.00) h, (0.17±0.00) h; T1/2 (ke) =(0.88±0.21) h,(0.51±0.05) h; MRT=(1.69±0.31) h, (0.99±0.06) h. Conclusion The pharmacokinetic parameters of aesculin by two routines showed significant difference, the ig route was with higher metabolic rate and can reduce blood uric acid effectively.关键词
秦皮甲素/药物动力学/给药途径/HPLCKey words
aesculin/pharmacokinetics/administration routine/HPLC分类
中医学引用本文复制引用
何群,姜宇,陈本超,陈光宇,郭锦明,谢名君..秦皮甲素两种给药途径在大鼠体内药代动力学研究[J].湖南中医药大学学报,2016,36(1):37-40,4.基金项目
湖南省教育厅计划课题(60010499). （60010499）
