川北医学院学报Issue(6)：748-751,4.DOI:10.3969/j.issn.1005-3697.2015.06.02
重型颅脑外伤术后颅内感染患者脑脊液高迁移率族蛋白-1和 RAGE 水平的变化及意义
Cerebrospinal fluid levels of high mobility group box-1 and RAGE in post-craniotomy of sever traumatic brain injury patients with intracranial infec-tion
摘要
Abstract
Objective:Observe the changes of cerebrospinal fluid(CSF)levels of High mobility group box 1 (HMGB-1 )and re-ceptor for advanced glycosylation end products (RAGE)in post-craniotomy of sever traumatic brain injury(sTBI)patients with in-tracranial infection.Methods:The CSF concentrations of HMGB-1 and RAGE in post-craniotomy of sTBI patients with intracranial in-fection (n =12 ) and non-intracranial infection (n = 42 ) were measured by a quantitative enzyme-linked immunosorbent assay (ELISA).Receiver operating characteristic (ROC)curve verified the diagnostic value of HMGB-1 and RAGE protein levels in CSF. Results:CSF levels of HMGB-1 and RAGE in intracranial infection group were significantly higher than non-intracranial infection group (t =6.71 1 ,P =0.000;t =2.683,P =0.008).Area under the curve (AUC)of HMGB-1 and RAGE ROC curve were 0.899 (95%CI:0.822 ~0.975),0.682 (95% CI:0.555 ~0.809),respectively.The best cut-off value of HMBG-1 for a diagnosis of intracranial infection was 209.50 ng /mL (sensitivity and specificity were 0.75 and 0.93),the best cut-off value of HMBG-1 was 108.50 ng /mL (sensitivity and specificity were 1 .00 and 0.43).Conclusion:The CSF levels of HMGB-1 and RAGE were found to suitable biomark-ers for diagnosing intracranial infection.关键词
重型颅脑外伤/颅内感染/高迁移率族蛋白-1/晚期糖基化终产物受体/受试者工作曲线Key words
Sever traumatic brain injury/Intracranial infection/High mobility group box-1/Receptor for advanced glycosylation end products/Receiver operating characteristic curve分类
医药卫生引用本文复制引用
戴新贵,付春来,张圣岸,黎艳晖,郭伟,蔡业平..重型颅脑外伤术后颅内感染患者脑脊液高迁移率族蛋白-1和 RAGE 水平的变化及意义[J].川北医学院学报,2015,(6):748-751,4.基金项目
郴州市第一人民院科研项目 （）
