川北医学院学报Issue(6)：816-819,4.DOI:10.3969/j.issn.1005-3697.2015.06.20
ER、PR 在分化型甲状腺癌组织中的表达及临床意义
Expression and clinical significance of ER and PR in differentiated thyroid carcinoma tissue
李励琦 1杭剑萍1
作者信息
- 1. 江南大学附属无锡第四人民医院甲状腺乳腺外科，江苏 无锡 214000
- 折叠
摘要
Abstract
Objective:To explore the expression and clinical significance of estrogen receptor (ER)and progesterone receptor (PR)in differentiated thyroid carcinoma tissue.Methods:A total of 98 samples with thyroid tumors archived in Department of Patholo-gy in The Fourth People’s Hospital of Wuxi were selected as research objects.The expression of ER and PR in the thyroid tumor tis-sues was respectively detected using immunohistochemical SP method,and their correlations in papillary thyroid carcinoma (PTC)and follicular thyroid carcinoma (FTC)tissues were analyzed.Results:The positive expression rates of ER and PR in PTC and FTC tissues were dramatically higher than in thyroid adenoma and nodular goiter tissues,with statistical significance (P <0.05 or P <0.01 ).The positive expression rates of ER and PR in the patients with PTC and <45 years old were also higher than in those ≥45 years old,and significant difference was presented (P <0.01 ).The expressions of ER and PR in PTC and FTC tissues had significantly positive cor-relations (r =0.025,P =0.018;r =0.278,P =0.035 ).Conclusion:The expression of ER and PR in thyroid tumor tissue can be used as a reference index in the identification of benign and malignant tumors.关键词
雌激素受体/孕激素受体/甲状腺癌/免疫组化Key words
Estrogen receptor/Progesterone receptor/Thyroid cancer/Immunohistochemistry分类
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李励琦,杭剑萍..ER、PR 在分化型甲状腺癌组织中的表达及临床意义[J].川北医学院学报,2015,(6):816-819,4.
