摘要
Abstract
Objective:To explore the correlation of serum homocysteine (Hcy)level and carotid arteriosclerosis in the patients with cerebral infarction.Methods:A total of 132 patients with cerebral infarction were selected as observation group,36 healthy people without cardiovascular disease were as healthy control group.The level of serum Hcy in all subjects was detected by enzymatic cycling assay and the carotid intima-media thickness (IMT)of all patients was checked using color Doppler echocardiography.According to IMT degree,the patients in observation group were divided into IMT normal group,IMT mild-stenosis group and IMT moderate,se-vere-stenosis group.The level of Hcy between observation group and control group as well as each subgroup of observation group was compared,and its correlation with IMT was also analyzed.Results:The level of Hcy in observation group was higher than in healthy control group (P <0.01 ).The incidence of increased Hcy (78.79%,104 /132)in the patients with carotid arteriosclerosis (IMT mild + moderate,severe-stenosis groups was dramatically higher than in IMT normal group (P <0.01 ).The level of Hcy was IMT moderate,severe-stenosis group >IMT mild-stenosis group >IMT normal group (P <0.01 or P <0.05).Pearson correlation analysis displayed that the level of Hcy was positively correlated with IMT (r =0.863,P =0.000).Conclusion:The level of Hcy in the patients with cerebral infarction is positively correlated with the severity of carotid arteriosclerosis,suggesting that high Hcy is closely related to the occurrence and progression of carotid arteriosclerosis,conductive to early prevention,intervention and prognostic assessment of cer-ebral infarction.关键词
脑梗死/同型半胱氨酸/颈动脉粥样硬化/相关性Key words
Cerebral infarction/Homocysteine/Carotid arteriosclerosis/Correlation分类
医药卫生
