重庆医学Issue(36)：5095-5097,5100,4.DOI:10.3969/j.issn.1671-8348.2015.36.015
N T-proBNP 在判断 ACS 患者冠状动脉病变程度和短期预后中的价值
Value of NT-proBNP in predicting severity of coronary artery disease and prognosis in acute coronary syndrome
摘要
Abstract
Objective To assess the in-hospital prognostic value of NT-proBNP in patients with acute coronary syndrome (ACS) and its relation to the severity and prognosis of coronary artery disease .Methods Totally 132 consecutive patients with ACS in Affiliated Hospital of Nantong University from January 2013 to December 2014 were collected in this study ,in which 64 pa-tients with unstable angina(UA) ,46 patients with non-ST segment elevation myocardial infarction(NSTEMI) ,and 22 patients with ST segment elevation myocardial infarction(STEMI) .Patients were divided into two high NT-proBNP group(NT-proBNP ≥ 474 pg/mL) and low NT-proBNP group(NT-proBNP < 474 pg/mL ) .Ejection fraction were detected and compared between the two groups ,coronary artery disease were detected by coronary angiography .cTnI ,CK-MB ,CRP and NT-proBNP were detected by sero-logical ,and the average length of hospital stay and heart failure ,cardiac shock incidence were calculated .Results There was a sig-nificant negative correlation between NT-proBNP and ejection fraction .Incidence of heart failure and duration of hospital stay in high NT-proBNP group were significantly higher than in low NT-proBNP group ;The number of coronary vessels affected ,severity of stenosis and proximal left anterior descending artery(LAD) disease in high NT-proBNP group were higher than in low NT-proB-NP group ;TIMI flow grade was significantly lower in high NT-proBNP group than in low NT-proBNP group ,the difference was statistically significant(P< 0 .05) .Conclusion NT-proBNP is a valuable marker for predicting prognosis and severity of coronary artery disease in patients with acute coronary syndrome .关键词
急性冠状动脉综合征/N 端脑钠肽前体/冠状动脉狭窄Key words
acute coronary syndrome/NT-ProBNP/coronary stenosis分类
医药卫生引用本文复制引用
张剑,陆齐..N T-proBNP 在判断 ACS 患者冠状动脉病变程度和短期预后中的价值[J].重庆医学,2015,(36):5095-5097,5100,4.基金项目
南通科技局社会事业科技创新与示范基金资助项目（S11954）。 （）
