健康研究Issue(6)：635-637,3.DOI:10.3969/j.issn.1674-6449.2015.06.014
矽尘接触者及患者氧化应激指标及TGF-β1和 TNF-α的变化
Variation of oxidative stress and TGF-β1 & TNF-αlevels in the serum of workers exposed to silica dust and silicosis patients
娄懿 1王淑娟 1贾仰民 1李国辉1
作者信息
- 1. 杭州市红十字会医院 职业病科，浙江 杭州 310000
- 折叠
摘要
Abstract
Objective To examine the effect of continuous renal replacement ( CRRT) and that of intermittent hemodialysis ( IHD) on severe acute kidney injury ( AKI) and to analyze the factors affecting the prognosis .Method 230 patients with severe AKI were randomly divided into two groups , a control group ( n=115 ) cases and an experimental group ( n=115 ) . The experimental group was given the continuous renal replacement therapy .The control group was treated with intermittent hemodialysis .The effects of CRRT and that of IHD were then compared .The factors affecting the prognosis were also analyzed.Findings The BUN, Scr, and APACHE-II scores of both groups after treatment were significantly decreased .The scores of the CRRT group decreased more significantly (P <0.01).The HCO3-of the CRRT group increased more significantly (P<0.01).The mortality rate of the CRRT group was significantly lower than that of the IHD group .Old age (OR=3.105), the number of organ failure (OR=4.718), APACHEII scores (OR=3.693), severe underlying diseases (OR=7.847), were independent risk factors causing death in patients with severe AKI (P<0.05.Conclusion Compared with IHD, the effect of CRRT treatment of severe AKI is more significant .The survival rate was high and better able to maintain a stable internal environment .Old age, the number of organ failure, APACHEII scores, and severe underlying diseases are independent risk factors causing death in patients with severe AKI .关键词
矽肺/氧化应激/转化生长因子-β1/肿瘤坏死因子-αKey words
Continuous renal replacement/intermittent hemodialysis/severe acute renal failure/prognosis/factors分类
医药卫生引用本文复制引用
娄懿,王淑娟,贾仰民,李国辉..矽尘接触者及患者氧化应激指标及TGF-β1和 TNF-α的变化[J].健康研究,2015,(6):635-637,3.
