摘要
Abstract
Objective To explore the correlation of urine trace albumin/creatinine ratio ( UACR) to peripheral neuropathy in type 2 diabetes patients .Method 161 patients with type 2 diabetes were divided into diabetes peripheral neuropathy group (DPN group, n=102) and the diabetic peripheral neuropathy group (NDPN group, n=59) according to the peripheral neuropathy.The general clinical data, biochemical index, and UACR of the two groups were compared.Then the Logistic regression model was used to analyze the related risk factors resulting in peripheral neuropathy .Findings The diabetes duration, fasting plasma glucose (FPG), 2h postprandial blood glucose (2hPG), glycosylated hemoglobin (HbA1c), low density lipoprotein cholesterol (LDL-C), and UACR of the DPN group were significantly higher than those of the NDPN group (P<0.05).The fasting C peptide of the DPN group was significantly lower than that of the NDPN group (P<0.05);Logistic regression analysis showed that the diabetes duration , FPG , 2hPG, HbA1c, UACR were high risk factors for DPN (P<0.05).The ROC curve of UACR prediction of peripheral neuropathy was 0.835.The sensitivity and specificity were 82.9%and 85.1% respectively.The best diagnostic point was 11.14 mg/g.Conclusion UACR in patients with type 2 diabetes is positively correlated with related blood sugar index and is the risk factor of peripheral neuropathy .关键词
糖尿病/尿微量白蛋白与尿肌酐比值/周围神经病变/危险因素Key words
diabetes/urine trace albumin/creatinine ratio/peripheral neuropathy/risk factors分类
医药卫生
