检验医学与临床2016，Vol.13Issue(2)：150-152,3.DOI:10.3969/j.issn.1672-9455.2016.02.003
苦参对急性白血病患者 sICA M-1 和 sVCA M-1 水平的影响
Effects of radix sophorae flavescentis on serum levels of sICAM-1 and sVCAM-1 in patients with acute leukemia
摘要
Abstract
Objective To investigate the effect of radix sophorae flavescentis on the levels of soluble intercellu-lar adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1(sVCAM-1) in the patients with a-cute leukemia .Methods 60 cases of acute leukemia in our hospital from March 2013 to March 2015 were selected and divided into the conventional chemotherapy group and the radix sophorae flavescentis therapy group according to dif-ferent therapeutic methods ,30 cases in each group .The conventional chemotherapy group was given the routine chemotherapy regimen for implementing the therapy ,while on this basis the radix sophorae flavescentis therapy group was added with radix sophorae flavescentis .Contemporaneous 60 individuals undergoing the healthy physical exami-nation were selected as the healthy control group .The levels of serum sICAM-1 and sVCAM-1 before and after treat-ment in the patients with acute leukemia and the healthy individuals of physical examinations were detected by using ELISA .Results The serum sICAM-1 ,sVCAM-1 levels before and after treatment in the patients with acute leuke-mia were significantly higher than those in the healthy control group ,the difference was statistically significant (P<0 .05) .The serum sICAM-1 and sVCAM-1 levels in the conventional chemotherapy group and the radix sophorae fla-vescentis therapy group were decreased after treastment ,but the decrease degree in the radix sophorae flavescentis therapy group was more significant compared with the conventional chemotherapy group ,the difference was statisti-cally significant(P<0 .05) .The effective rate in the radix sophorae flavescentis therapy group was 90 .00% ,which was significantly higher than 67 .67% in the conventional chemotherapy group ,the difference was statistically signifi-cant (P<0 .05) .Conclusion Radix sophorae flavescentis can obviously reduce the serum sICAM-1 and sVCAM-1 levels ,improves the curative effect of conventional chemotherapy drugs and promotes the recovery in the patients w ith acute leukemia .关键词
苦参/急性白血病/可溶性细胞间黏附分子-1/可溶性血管细胞黏附分子-1Key words
radix sophorae flavescentis/acute leukemia/soluble intercellular adhesion molecule-1/solu-ble vascular cell adhesion molecule-1引用本文复制引用
马玲娣,唐跃华,董艳芬,朱志超,蒋丽佳,何晓清,刘娟..苦参对急性白血病患者 sICA M-1 和 sVCA M-1 水平的影响[J].检验医学与临床,2016,13(2):150-152,3.基金项目
国家自然科学基金资助项目(81101647 ). （81101647 ）
