检验医学与临床2016，Vol.13Issue(2)：157-159,3.DOI:10.3969/j.issn.1672-9455.2016.02.005
支气管激发试验在哮喘患者激素治疗后长期效果分级中的应用
Application of bronchial provocation test in long-term effect grading of hormone therapy for asthma patients
摘要
Abstract
Objective To study the application of bronchial provocation test (BPT ) in the long-term clinical prognosis grading of hormone therapy in asthma patients .Methods 120 inpatients with bronchial asthma in the Hefei Municipal Second People′s Hospital from March 2013 to March 2015 were selected and treated with inhaled sugar cortical hormone for controlling the asthmatic symptoms ,beclomethasone and triamcinolone ,200 -400 μg each time ,three times a day ,for continuous 3 months .According to different concentrations of inhaled acetylcholine , the patients were divided into 10 groups of 49 ,98 ,195 ,390 ,781 ,1 563 ,3 125 ,6 250 ,12 500 and 25 000 μg/mL ,and the BPT test was performed .BPT was reviewed before treatment and at 3 ,6 ,12 ,24 months after treatment ,and the positive rate of airway high reaction (AHR) was compared .Results 85 cases were the AHR positive before treat-ment with the positive rate of 70 .8% ,which was decreased after treatment ;the AHR positive rate at 2 ,6 ,12 ,24 months after treatment was related to the concentration of acetylcholine ,which was decreased with the acetylcholine concentration increase .According to the influence of different acetylcholine concentrations on the AHR positive rate , two stages of levels were appeared ,i .e .,49-3 125 μg/mL and 6 250-25 000 μg/mL .The Kaplan-Meier method analysis showed that the average positive case number in 9 -3 125 μg/mL was 22 .00 cases which was more than 5 .25 cases in 6 250-25 000 μg/mL ,and the positive rate after 3 ,6 ,12 ,24 months treatment in the stage of 49-3 125 μg/mL was higher than that in the stage of 6 250-25 000 μg/mL ,the difference was statistically significant (P<0 .05) .By the Cox regression analysis ,the risk ratio in the stage of 49 -3 125 μg/mL was 0 .89 ,which was more than 0 .73 in the stage of 6 250-25 000 μg/mL ,prompting that the prognosis effect in the stage of 49-3 125μg/mL was poorer than that in the stage of 6 250-25 000μg/mL .Conclusion The curative effects in the asthmatic patients after long-term glucocoticoid treatment can be performed the classification according to BPT .The inhaled acetylcholine concentration in 49-3 125 μg/mL is a high recurrence stage ,w hile w hich in 6 250-25 000 μg/mL is a low recurrence stage .关键词
支气管激发试验/支气管哮喘/预后分级Key words
bronchial provocation test / bronchial asthma / prognosis classification引用本文复制引用
昂朝海,费广鹤..支气管激发试验在哮喘患者激素治疗后长期效果分级中的应用[J].检验医学与临床,2016,13(2):157-159,3.基金项目
国家自然科学基金资助项目(81070020 ). （81070020 ）
