检验医学与临床2016，Vol.13Issue(2)：192-195,4.DOI:10.3969/j.issn.1672-9455.2016.02.017
人表皮生长因子受体3在乳腺癌组织中的表达及临床意义
Expression and clinical significance of HER3 in breast carcinoma tissue
房慧颖 1张丽杰 2曾晓华 1辇伟奇1
作者信息
- 1. 重庆市肿瘤研究所乳腺科 400030
- 2. 哈尔滨医科大学附属肿瘤医院肿瘤内科 ,哈尔滨 150006
- 折叠
摘要
Abstract
Objective To investigate the expression of human epithelial growth factor receptor-3(HER3) in breast cancer tissue and its correlation with clinicopathological characteristics and prognosis .Methods The immuno-histochemical method was used to detect the HER3 expression in 126 specimens of breast cancer tissue .The relation between its expression with age ,menstruation situation ,tumor size ,TNM stage ,lymph node metastasis ,estrogen receptor(ER) ,progesterone receptor(PR) ,HER2 and prognosis was analyzed .Results (1)The positive expression rate of HER3 in breast cancer tissue was 30 .2% .The HER3 positive expression in the breast cancer menopausal pa-tients was 43 .3% ,which was higher than 18 .2% in the non-menopausal ones(P<0 .05) ,and the HER3 positive expression in the patients with positive lymph nodes metastasis was 40 .0% ,which was higher than 21 .2% in the non-lymph node metastasis ones ,the differences were statistically significant(P<0 .05);and the HER3 positive ex-pression in the breast cancer patients with HER2 positive was 42 .5% ,which was higher than 24 .4% in the patients with non-HER2 positive ,the difference was statistically significant(P<0 .05) .(2) The 5-year disease-free survival (DFS) rate in the HER3 positive patients was lower (P<0 .05) .(3) The lymph node metastasis rate in the patients with both HER3 and HER2 positive was significantly higher (P<0 .05) .Conclusion The HER3 expression plays an important role in the development of breast cancer and influences its prognosis ,therefore HER3 could be used as an indicator for judging the prognosis of breast cancer and a target point of clinical therapy .关键词
乳腺癌/人表皮生长因子受体3/免疫组织化学Key words
breast carcinoma/human epidermal growth factor receptor 3/immunohistochemistry引用本文复制引用
房慧颖,张丽杰,曾晓华,辇伟奇..人表皮生长因子受体3在乳腺癌组织中的表达及临床意义[J].检验医学与临床,2016,13(2):192-195,4.
