摘要
Abstract
AIM:To observe the effect and safety of Ranibizumab intravitreaI injection combined with Iaser photocoaguIation in treatment of macuIar edema secondary to branch retina vein occIusion ( BRVO) . METHODS:Forty-four patients (44 eyes) with macuIar edema secondary to BRVO were enroIIed. Patients received intravitreaI injection of ranibizumab ( 0. 05mL/0. 5mg) and Iaser photocoaguIation (ranibizumab group) or Iaser photocoaguIation aIone ( controI group ) . Patients in ranibizumab group were given Iaser photocoaguIation at 1mo after intravitreaI injection. Then ranibizumab was given again if needed. The best corrected visuaI acuity ( BCVA ) , sIitIamp examination, fundus examination, non - contact tonometer examination and fundus fIuorescein angiography were taken. AII patients were foIIowed up for 6mo. We anaIyzed the changes on BCVA,centraI macuIar thickness ( CMT) before and 1,4,12 and 24wk after treatments, and reIated compIications were recorded. RESULTS: Outcomes are significantIy better in ranibizumab group with reduced retinaI thickness and improved visuaI acuity. In ranibizumab group, both visuaI acuity and CMT vaIues were significantIy better than those before treatments ( visuaI acuity:t = 5. 781, 7. 496,7. 341,7. 836, aII P=0. 000;CMT:t=9. 784,11. 893, 11. 573,11. 437, aII P = 0. 000 ). In controI group, the improvement on visuaI acuity was not significantIy better than that before treatment at 1wk ( t=2. 130, P=0. 053 );whiIe the improvement on visuaI acuity was significantIy better at 4,12 and 24wk(t=3. 524,6. 429,6. 922,P=0. 04, 0. 000,0. 000). The improvements on visuaI acuity after treatments in ranibizumab group were significantIy better than those in controI group at 1,4,12 and 24wk(t=2. 604, 3. 223,3. 303,3. 296,P=0. 015,0. 03,0. 04,0. 03). CMT vaIues after treatments in ranibizumab group were significantIy better than those in contraI group at 1,4,12 and 24wk(t=43.231,50. 504,56. 074,38. 103,aII P=0. 000). No severe ocuIar and systematic side effect was found. CONCLUSION: IntravitreaI injection of ranibizumab combined with Iaser photocoaguIation was effective and safe for macuIar edema secondary to BRVO.关键词
视网膜分支静脉阻塞/黄斑水肿/激光光凝/雷珠单抗Key words
branch retinaI vein occIusion/macuIar edema/Iaser photocoaguIation/ranibizumab
