山东中医药大学学报2016，Vol.40Issue(1)：74-76,3.
蟾毒灵平衡溶解度和表观油水分配系数的测定
Determination of Equilibrium Solubility and Apparent Oil-water Partition Coefficients of Bufalin
摘要
Abstract
Objective:To determine equilibrium solubility and apparent oil-water partition coefficients of bufalin. Methods:High performance liquid chromatography(HPLC) method was used to determine equilibrium solubility of bufalin in water and sorts of organic solvent ,and apparent oil-water partition coefficients of bufalin was determined by shake flask method in n-caprylic alcohol-water buffer salt solution. Results:Equilibrium solubility of bufalin was greater in alkaline environment than in acid environment at 25℃ and 37℃,but both greater than 10μg/mL. The solution rate of bufalin was relatively slow and it needed 34 hours to reach saturation. Apparent oil-water partition coefficients of bufalin had less effect on pH. LogP of bufalin was between 2.5 and 3.0 in different pH environment. Conclusion:Equilibrium solubility and apparent oil-water partition coefficients of bufalin are able to meet the requirements of druggability.关键词
蟾毒灵/平衡溶解度/表观油水分配系数Key words
bufalin/equilibrium solubility/apparent oil-water partition coefficients分类
医药卫生引用本文复制引用
孙沛霖,战兵,林桂涛..蟾毒灵平衡溶解度和表观油水分配系数的测定[J].山东中医药大学学报,2016,40(1):74-76,3.基金项目
济南市科技局高校自主创新项目(编号:JN100586) （编号:JN100586）
