生物安全学报Issue(4)：265-273,9.DOI:10.3969/j.issn.2095-1787.2015.04.003
分子模拟技术及其在苹果蠹蛾代谢杀虫剂分子机制研究中的应用进展
Molecular simulation and its application progress on molecular metabolic mechanisms of insecticide in Cydia pomonella
摘要
Abstract
The codling moth, Cydia pomonella( L.) ( Lepidoptera: Tortricidae) is a major global pest of pome fruits, and it was considered a serious invasive species, threatening the safety of fruit production areas in Loess Plateau and Bohai Bay. The effective management of the codling moth mainly depends on chemical insecticides. However, a major problem associated with chemical con￣trol of the codling moth is the development of insecticide￣resistance worldwide. Among them, metabolic resistance is the main mech￣anism for C. pomonella resistance. To understand the metabolic mechanisms of insecticide resistance in C. pomonella, the molecular changes of detoxification enzymes were examined. Molecular simulation based methods can be important for such related research. This paper reviews the molecular simulation methods and its application in elucidating molecular metabolic mechanisms of insecticide resistance in C. pomonella. Future potential research directions using molecular simulation are put forward.关键词
苹果蠹蛾/分子模拟/解毒酶/杀虫剂/代谢抗性Key words
Cydia pomonella/molecular simulation/detoxifying enzyme/insecticide/metabolic resistance引用本文复制引用
杨雪清,刘吉元,张雅林..分子模拟技术及其在苹果蠹蛾代谢杀虫剂分子机制研究中的应用进展[J].生物安全学报,2015,(4):265-273,9.基金项目
国家公益性行业(农业)科研专项(200903042)；国家自然科学基金(31501666) （农业）
