首页|期刊导航|中国当代儿科杂志|白细胞介素-4受体基因多态性及IgE水平与哮喘预测指数相关性研究

白细胞介素-4受体基因多态性及IgE水平与哮喘预测指数相关性研究OA北大核心CSCDCSTPCDMEDLINE

Correlations of IL-4R gene polymorphism and serum IgE levels with asthma predictive index

中文摘要英文摘要

目的:研究新疆维吾尔自治区儿童白细胞介素-4受体(IL-4R)基因多态性及IgE水平与哮喘预测指数(API)的相关性。方法选取167例API(+)、187例API(-)及203例健康婴幼儿(对照组),应用PCR聚合酶链反应和DNA测序法进行基因分型。同时ELISA法检测三组婴幼儿血清IgE水平。结果 IL-4R基因Arg551Gln位点各基因型频率分布在API(+)组、API(-)组、对照组三组中差异无统计学意义(P>0.05);AP…查看全部>>

ObjectiveTo study the correlations of IL-4R gene polymorphism and serum IgE levels with asthma predictive index (API) in children.MethodsOne hundred and sixty-seven children with positive API, 187 children with negative API and 203 healthy children (control group) were enrolled. PCR and DNA sequencing were used to identify genotypes of the Arg551Gln locus in IL-4R gene. Serum IgE levels were measured using ELISA.Results There was no significant difference in…查看全部>>

王建荣;冯瑞华;多力坤·木扎帕尔

新疆医科大学第五附属医院儿科,新疆 乌鲁木齐 830011新疆医科大学第五附属医院儿科,新疆 乌鲁木齐 830011新疆医科大学第一附属医院儿科,新疆 乌鲁木齐 830054

哮喘哮喘预测指数白细胞介素-4受体IgE儿童

Asthma predictive indexIL-4RIgEChild

《中国当代儿科杂志》 2015 (12)

1306-1310,5

新疆医科大学科研创新基金资助项目(XJC2013178)。

10.7499/j.issn.1008-8830.2015.12.010

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